|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this chapter we will review literatures describing the functional organization of the AgRP circuit and its correlative signaling components that influence ingestive, foraging, motivational, and cognitive responses, a framework that reshaped our thinking toward the new hope and challenges in treatment of obesity and eating disorders.
|
30390282 |
2019 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In multivariable analysis, the greatest risk factor for developing obesity was the use of an INSTI as the primary ART core drug (adjusted HR 7.12, P < 0.0001); other risk factors included younger age, female sex, higher baseline BMI, lower baseline CD4+ T lymphocyte count, higher baseline HIV-1 RNA, hypertension and diabetes mellitus.
|
29722811 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The median ART duration was 57 months (IQR: 27-85); 46.7% were in WHO stage III/IV at ART initiation, 88.2% had exposure to efavirenz and 9% were overweight or obese.
|
29155891 |
2017 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population.
|
26226973 |
2016 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increasing our understanding of how αMSH and AgRP act on dopamine pathways to affect behavior may allow for identification of new strategies to combat disorders involving dysfunction of dopamine pathways, such as obesity and drug abuse.
|
26116876 |
2015 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, Gpr83 knock-out mice have normal body weight and glucose tolerance when fed a regular chow diet, but are protected from obesity and glucose intolerance when challenged with a high-fat diet, despite hyperphagia and increased hypothalamic expression of agouti-related protein, Npy, Hcrt and Ghsr1a.
|
23744028 |
2013 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to assess the genetic variability of AGRP gene and investigate whether the previously reported SNP rs5030980 and the rs11575892, a SNP that so far has not been studied with respect to obesity is associated with increased body mass index (BMI).
|
19602223 |
2009 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
While forced activation of hypothalamic IKKbeta/NF-kappaB interrupts central insulin/leptin signaling and actions, site- or cell-specific suppression of IKKbeta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance.
|
18854155 |
2008 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
RGD |
By contrast, although there was the expected increase in both NPY and AGRP expression in obese 14-week-old ZF rats, the expression of NPY and AGRP was decreased in 6-week-old obese ZDF rats with hyperinsulinaemia and in 14-week-old rats with the additional hyperglycaemia.
|
18001323 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status.
|
16130030 |
2006 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The currently available data suggest that elevated AGRP mRNA along with reduced proopiomelanocortin (POMC) mRNA is associated with many types of obesity and agents antagonizing the effect of AGRP may be a potential therapeutic target in treating obesity and obesity-associated disorders in which endogenous hypothalamic AGRP is elevated.
|
14572167 |
2003 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion.
|
12213871 |
2002 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.
|
11554767 |
2001 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in AGRP and alpha MSH genes were not among the causes of obesity in our population.
|
11487744 |
2001 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This variable expressivity of MC4-R-associated obesity is not due to variations in genes for alpha-MSH or AGRP.
|
10903341 |
2000 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation.
|
9311920 |
1997 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.210 |
Biomarker
|
disease |
RGD |
Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats.
|
18001323 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.210 |
Biomarker
|
disease |
BEFREE |
A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.
|
11554767 |
2001 |
|
Hyperphagia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was associated with a 286.6+/-4.4% increase in hypothalamic AGRP mRNA and a 178.9+/-13.5% increase in hypothalamic NPY mRNA.
|
11179781 |
2001 |
|
HIV Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We included 264 ART regimens: 75.6% male, median (IQR) age 47 years (39-53), 7 years (3-16) of HIV infection, nadir CD4+ 247 cells/mm3 (105-361), 81.5% with VL ≤50 copies/mL and 11.7% with at least one NRTI mutation at baseline.
|
31605107 |
2020 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: ART, antiretroviral therapy; CI, confidence interval; Hib, <i>Haemophilus influenza</i> type b; HIV, human immunodeficiency virus; HIV+PCV-, HIV-infected, placebo-vaccinated group; HIV+PCV+, HIV-infected, PCV9-vaccinated group; HIV-PCV-, HIV-uninfected, placebo-vaccinated group; HIV+PCV+, HIV-infected, PCV9-vaccinated group; IBI, invasive bacterial infection; IPD, invasive pneumococcal disease; IRR, incidence rate ratio; IQR, interquartile range; OR, odds ratio; PCV, pneumococcal conjugate vaccine; PCV7, 7-valent pneumococcal conjugate vaccine; PCV9, 9-valent pneumococcal conjugate vaccine; PY, person-years; RCT, randomised control trial.
|
31156062 |
2020 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Changes in ART Adherence Relate to Changes in depression as Well! Evidence for the Bi-directional Longitudinal Relationship Between Depression and ART Adherence from a Prospective Study of HIV Clients in Uganda.
|
31813077 |
2019 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Thailand, substance use was not significantly associated with VL undetectability or ART adherence, but alcohol misuse among MSM was associated with increased odds of depression (AOR = 2.75; 95% CI 1.20, 6.32, p = 0.02).
|
30725397 |
2019 |