Diarrhea
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Intestinal epithelial apical membrane Cl-/HCO3- exchanger DRA (downregulated in adenoma, SLC26A3) has emerged as an important therapeutic target for diarrhea, emphasizing the potential therapeutic role of agents that upregulate DRA.
|
31634391 |
2020 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Congenital chloride losing diarrhea (CCLD) is a rare type of chronic watery diarrhea due to mutations in SLC26A3 gene leading to defective chloride-bicarbonate exchanges with the resultant loss of chloride and retention of bicarbonate.We aim to define pediatric Saudi CCLD patients' characteristics to achieve prompt diagnosis, management, follow up with good quality of life, and prevention of complications in these patients.We carried retrospective data review of demographic, clinical, laboratory, radiographic, and outcome of all pediatric patients fulfilling the criteria of CCLD over 10 years from 2004 to 2014 from a single center in Taif region, Saudi Arabia.Forty-nine patients fulfilled the criteria of CCLD from 21 families with more than one affected patient in the same family in 90% of them and positive consanguinity in 91% of the cohort.
|
31145360 |
2019 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Patients with congenital chloride diarrhea (CLD) suffer from Cl<sup>-</sup> -rich acidic diarrhea and systemic alkalosis due to SLC26A3 mutations.
|
30873581 |
2019 |
Diarrhea
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
In summary, our studies, for the first time, demonstrate transcriptional regulation of DRA expression by CDX2, implying that reduced expression of DRA in inflammatory bowel disease-associated diarrhea may, in part, be due to downregulation of CDX2 in the inflamed mucosa.<b>NEW & NOTEWORTHY</b> SLC26A3 [downregulated in adenoma (DRA)] mediates intestinal luminal NaCl absorption and is downregulated in inflammatory bowel disease-associated diarrhea.
|
28572085 |
2017 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
A plethora of human diseases are associated with mutations in the genes encoding human SLC26 transporters, including chondrodysplasias with varying severity in SLC26A2 (~50 mutations, 27 point mutations), congenital chloride-losing diarrhea in SLC26A3 (~70 mutations, 31 point mutations) and Pendred Syndrome or deafness autosomal recessive type 4 in SLC26A4 (~500 mutations, 203 point mutations).
|
28941661 |
2017 |
Diarrhea
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
Further, GLP-1-SSM alleviated diarrhea (as assessed by luminal fluid) by increasing protein expression of intestinal chloride transporter DRA (down regulated in adenoma).
|
27553076 |
2017 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Rare mutation in the SLC26A3 transporter causes life-long diarrhoea with metabolic alkalosis.
|
25568271 |
2015 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3.
|
18216024 |
2008 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Congenital chloride diarrhea (CLD) is a rare, autosomal recessive disorder of intestinal Cl/HCO3 exchange caused by mutations in the SLC26A3 gene and characterized by persistent Cl rich diarrhea from birth.
|
16641574 |
2006 |
Diarrhea
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes.
|
12651923 |
2003 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The metabolic alkalosis of congenital chloride-losing diarrhea is caused by mutations in the DRA Cl(-)/HCO3(-) exchanger of the ileocolonic apical membrane.
|
11826292 |
2002 |
Diarrhea
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
A novel mutation of the down-regulated in adenoma gene in a Japanese case with congential chloride diarrhea. Mutations in brief no. 198. Online.
|
10671059 |
1998 |
Diarrhea
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
We conclude that DRA is an intestinal anion transport molecule that causes chloride diarrhoea when mutated.
|
8896562 |
1996 |
Diarrhea
|
0.200 |
Biomarker
|
phenotype |
HPO |
|
|
|