DRD1, dopamine receptor D1, 1812

N. diseases: 181; N. variants: 8
Disease: Dyskinetic syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.060 GeneticVariation disease BEFREE Multiple Poisson regression analyses showed a protector effect to the occurrence of dyskinesia for individuals carrying of the DRD1 G/G genotype (PR 0.294; CI 0.09-0.87; p ≤ 0.020) after the threshold Bonferroni's. 31119645 2019
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.060 Biomarker disease BEFREE 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction. 30261284 2019
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.060 GeneticVariation disease BEFREE There was no difference in dyskinesia prevalence among carriers of various haplotypes in DRD1. 29191473 2018
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.060 AlteredExpression disease BEFREE PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. 23041629 2012
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.060 Biomarker disease BEFREE The pathogenesis of dyskinesia may result from divergent changes in dopamine D1 receptors (DRD1) and dopamine D2 receptors (DRD2) in the brain while aging. 21181138 2011
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.060 GeneticVariation disease BEFREE The polymorphisms of the dopamine receptor D1 gene were not associated with the risk of developing PD or peak-dose dyskinesias. 10534246 1999