DRD3, dopamine receptor D3, 1814

N. diseases: 199; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		0.070 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		0.070 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		0.070 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C2700438
Disease: MAJOR AFFECTIVE DISORDER 7
MAJOR AFFECTIVE DISORDER 7 		0.060 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C2700439
Disease: MAJOR AFFECTIVE DISORDER 8
MAJOR AFFECTIVE DISORDER 8 		0.060 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C2700440
Disease: MAJOR AFFECTIVE DISORDER 9
MAJOR AFFECTIVE DISORDER 9 		0.060 GeneticVariation disease BEFREE We have used both approaches to test for possible associations between alleles of the dopamine D3 receptor gene and bipolar affective disorder. 7573178 1995
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.040 Biomarker phenotype BEFREE Another receptor, the D3 dopamine receptor (DRD3), may be of additional interest since it is specifically located in the limbic area, and in particular in the nucleus accumbens which plays a significant role in the reward process of addiction behavior. 8825889 1995
CUI: C0003128
Disease: Anovulation
Anovulation 		0.020 GeneticVariation phenotype BEFREE A dopamine D3 receptor genotype is associated with hyperandrogenic chronic anovulation and resistant to ovulation induction with clomiphene citrate in female Hispanics. 7890062 1995
CUI: C0233401
Disease: Psychiatric symptom
Psychiatric symptom 		0.020 GeneticVariation phenotype BEFREE Dopamine D3 receptor gene polymorphism and the psychiatric symptoms seen in first-break schizophrenic patients. 8746409 1995
CUI: C0429468
Disease: Anovulatory (finding)
Anovulatory (finding) 		0.020 GeneticVariation disease BEFREE A dopamine D3 receptor genotype is associated with hyperandrogenic chronic anovulation and resistant to ovulation induction with clomiphene citrate in female Hispanics. 7890062 1995
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Our results suggest that an association between the dopamine D3 receptor gene and schizophrenia is unlikely to exist. 8837704 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia. 8641685 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Proposed schizophrenia-related gene polymorphism: expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system. 8780735 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE A missense polymorphism (glycine to serine) in the first exon of the dopamine D3 (DRD3) gene was examined in the sib-pairs schizophrenia collection by the transmission test for linkage disequilibrium (TDT). 8723055 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia. 8678117 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE It has been reported an association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus. 8994215 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Association study of schizophrenia and the dopamine D3 receptor gene locus in two independent samples. 8950407 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE This seems to indicate that homozygosity for the Gly9/Ser9 polymorphism at the DRD3 locus is unlikely to confer susceptibility to schizophrenia in the German population. 8794508 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE In conclusion the accumulated data suggest strongly that genetic variation at the DRD3 locus increases susceptibility of schizophrenia, at least in males. 9118322 1996
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 Biomarker disease BEFREE These results strongly suggest that the dopamine D3 receptor is not associated with alcoholism. 8837712 1996
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 GeneticVariation disease BEFREE No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample. 9149327 1996
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 GeneticVariation disease BEFREE No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample. 9149327 1996
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.030 GeneticVariation disease BEFREE DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. 9154247 1996
CUI: C0221765
Disease: Chronic schizophrenia
Chronic schizophrenia 		0.030 AlteredExpression disease BEFREE Enhanced cleavage of an atypical intron of dopamine D3-receptor pre-mRNA in chronic schizophrenia. 8987818 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia. 9034004 1997