|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (P = 0.032), DRD4 (P = 0.05), MB-COMT (P = 0.009), and AKT1 (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively), and to a lesser degree in some of the candidate genes in non-psychotic patients versus the control subjects.
|
27753212 |
2016 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that DRD3 mRNA levels may serve as a potential diagnostic biomarker differentiating patients with early psychosis from controls.
|
26561806 |
2015 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
rs4680" genes_norm="1312">Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and rs6280" genes_norm="1814">Ser9Gly (rs6280; DRD3) polymorphisms were analyzed in a sample of 84 adolescent Caucasian patients with first-episode psychosis (ages 11-17) and 85 healthy Caucasian controls (ages 10-17).
|
18351593 |
2008 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this first phase of the project, the objective was to investigate the distribution of four candidate genetic polymorphisms for functional psychosis (Ser9Gly DRD3, 5HTTLPR, the VNTR 3'-UTR SLC6A3 and Val66Met BDNF) in a case-control sample.
|
19142409 |
2008 |
|
Psychotic Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our findings suggest that the expression of DRD3 mRNA is reduced in schizophrenia and bipolar disorder, supporting the hypothesis of distorted homeostasis of dopamine receptor subtypes in psychotic disorder.
|
15539862 |
2004 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Risk of schizophrenia and psychosis in Alzheimer's disease (AD) has been linked to polymorphic variation at the dopamine receptor DRD3 gene implying similar causative mechanisms.
|
15342129 |
2004 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 TaqI A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis.
|
15564898 |
2004 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In Alzheimer disease, hallucinations and psychosis have been linked to increased representations of B2/B2 homozyogotes for the dopamine receptor gene DRD1 and 1/1 or 2/2 homozygotes for DRD3.
|
11176958 |
2001 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study we investigated the possibility that variants of the DRD3 gene might be associated with symptomatology in a sample of subjects affected by major psychoses.
|
10490702 |
1999 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The joint risk for psychosis due to the DRD1 and DRD3 polymorphisms exceeded the risks due to either locus alone, suggesting an interaction.
|
9779662 |
1998 |