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Impulsive Behavior
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0.100 |
GeneticVariation
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phenotype |
BEFREE |
No clear consensus on the role of any individual gene variant in personality modulation emerged, although SLC6A4 haplotypes and the DRD4 rs1800955 promoter variant seemed to be more reliably related to anxiety and impulsivity-related traits, respectively.
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24100617 |
2014 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
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phenotype |
BEFREE |
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR, SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4) 5HTTLPR, COMT (Catechol-O-methyltransferase) Val158Met and DRD4 (dopamine D4 receptor) VNTR 1-11-that all have been found to be associated with an increased vulnerability for antisocial and impulsive behavior in response to aversive environmental conditions.
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24764243 |
2014 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
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phenotype |
BEFREE |
Studies of 3 common polymorphisms-the short and long variants of the serotonin-transporter-linked polymorphic region (5-HTTLPR), the variable number tandem repeat polymorphism in the 3' untranslated region of the dopamine active transporter gene (DAT1 3' UTR VNTR), and the 48 base-pair VNTR in exon-3 of the dopamine D4 receptor gene (DRD4)-and their effects on phenotypes of impulsivity were examined.
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24978691 |
2014 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.
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23713429 |
2013 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data suggest that the DRD4 -521 C/T polymorphism contributes to a "risk-taking phenotype" in skiers and snowboarders, but the variant was not associated with impulsive sensation seeking (P = 0.9).
|
23252368 |
2013 |
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Impulsive Behavior
|
0.100 |
Biomarker
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phenotype |
BEFREE |
Association analyses of these polymorphisms with the A-X CPT indices suggested a double dissociation such that an index of inattention was associated with DRD4 but not DAT1, and an index of impulsivity was associated with DAT1 but not DRD4.
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22564179 |
2012 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The 7 repeat allele of the DRD4 gene has likewise been associated with the performance in executive functions, as well as with addictive behaviors and impulsivity.
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22848508 |
2012 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Results showed lower impulsivity in the presence of the DRD4 7-repeat (P = 0.006) and the HTR1B rs13212041 alleles (P = 0.003).
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22259185 |
2012 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Men carrying the DRD4 7-repeat allele were more impulsive than those without.
|
21063133 |
2011 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Participants, who were also genotyped for the COMT(val158met) and DRD4(48bp-VNTR) polymorphisms, performed a hypothetical and a real-time discounting task and provided self-ratings of trait impulsivity.
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20736997 |
2010 |
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Impulsive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interaction effects between DAT1 and DRD4 and between DAT1 and the father ADHD risk group were found for child Hyperactivity-Impulsivity scores.
|
20421851 |
2010 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In addition, candidate polymorphisms of the DRD2 and DRD4 dopamine receptor genes were selected from the impulsive behavior literature.
|
20205808 |
2010 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In a sample of 130 healthy adults, we studied the relation between DAT1, DRD4, and C957T polymorphism at the DRD2 gene (polymorphisms related to striatal DA) and catechol-Omethyltransferase (COMT) Val158Met (a polymorphism related to frontal DA) on self-reported dysfunctional and functional impulsivity, assessed by the Dickman impulsivity inventory (DII), and the efficiency of inhibitory control, assessed by the stop-signal paradigm.
|
20678555 |
2010 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Therefore, the objectives of this study were: (1) to test whether a single session of MET increased motivation to reduce drinking and drinking outcomes; and (2) to examine whether genetic dopamine D(4) receptor L (DRD4 L) and individual personality risk factors (impulsivity and novelty seeking) moderated the effects of the MET.
|
19298319 |
2009 |
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Impulsive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The DRD4 gene may be associated with measures of novelty seeking and impulsivity but not extraversion.
|
17574217 |
2008 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The present study was therefore undertaken in a sample of healthy adults to investigate the influence of two candidate dopaminergic gene polymorphisms (DRD4 and DAT) on the endophenotype of impulsivity, which we operationalized as behavioral inhibition during the Stop-signal task.
|
17525955 |
2008 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The association of the DRD4 gene with hard drug use may support literature linking this gene to impulsivity.
|
17175015 |
2007 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Based on logistic regression and QTDT, the 5-repeat allele of DRD4 may confer protection for hyperactive-impulsivity symptom severity compared to the 4-repeat allele.
|
16165273 |
2005 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Recent work has identified a distinct polymorphism of the dopamine D4 receptor gene in normal people with a behavioral temperament profile characterized by features of "novelty seeking" which include impulsive and exploratory behaviors.
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15519116 |
2004 |
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Impulsive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Similar findings were obtained in relation to MPH response as analysis of MPH responders alone gave rise to a more significant association than that of the group as a whole (TDT chi2 = 4.9, P = 0.013). t-Test and logistic regression TDT analyses of DRD4*7 transmission with respect to dimensional rating scales of hyperactivity and impulsivity showed an inverse relation suggesting that in this sample DRD4*7 is associated with a lower level of ADHD symptomatology.
|
10889550 |
2000 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse.
|
10402503 |
1999 |
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Impulsive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This work provides a new evidence of the implication of the dopaminergic reward pathways, now through the involvement of DRD4, in the aetiology of this impulsive disorder.
|
9352568 |
1997 |
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Impulsive Behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We evaluated the DRD4 genotype in 226 Finish adult males, 113 of whom were alcoholics, many of the early onset type with features of impulsivity and antisocial traits.
|
7573171 |
1995 |