Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (P = 0.032), DRD4 (P = 0.05), MB-COMT (P = 0.009), and AKT1 (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively), and to a lesser degree in some of the candidate genes in non-psychotic patients versus the control subjects.
|
27753212 |
2016 |
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
DRD4 gene may play an important role in psychotic symptomatology rather than in unique diagnosis, BD, for example.
|
25233244 |
2015 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Significant associations were observed between the serotonin transporter gene (SERT) polymorphism STin2 and "psychosis"; the dopamine transporter gene (DAT) 3' variable number tandem repeats (VNTR) and "agitation"; and the dopamine receptor 4 (DRD4) VNTR and "moods" factors.
|
20685009 |
2012 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the present study, the DRD4 VNTR 7 repeat allele (7R) was examined in 477 patients with major psychoses.
|
22543114 |
2012 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A number of association studies between the DRD4 gene 48 bp-VNTR polymorphism at exon 3 and psychotic disorders have been reported, but the results have been controversial.
|
17822780 |
2007 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 TaqI A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis.
|
15564898 |
2004 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
DRD4 variants were not associated with symptomatology of major psychosis.
|
15364409 |
2004 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It has been suggested that some molecular variants of the DRD4 gene (e.g., four and seven alleles) could be implicated in the pathogenesis of psychotic disorders.
|
11282178 |
2001 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This analysis in an enlarged sample suggests that DRD4*Long alleles exert a small but significant influence on the delusional symptomatology in subjects affected by major psychoses.
|
11353451 |
2001 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results exclude that coding variants of the DRD4 exon 1 and 3 may play a major role in conferring susceptibility to major psychoses; moreover, we could not replicate the association of DRD4 exon 1 variant with delusional disorder.
|
10490704 |
1999 |
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The serotonin transporter gene does not, therefore, interact with DRD4 in determining the symptomatology of major psychoses.
|
10490703 |
1999 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
DRD4 variants may, therefore, constitute a liability factor for development of delusional symptomatology in patients with major psychoses.
|
10478793 |
1999 |
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The possible association of GABRA1 with the psychopathology of major psychoses was tested both alone and in interaction with DRD4.
|
10050966 |
1999 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Catalano et al reported an association between delusional disorder and the number of a 12-nucleotide (bp) repeat sequence in the first exon of dopamine D4 receptor gene (DRD4), which indicated a possible role of this polymorphism in the pathogenesis of psychotic disorders.
|
9532348 |
1998 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Neither the DRD2 S311C polymorphism nor the presence of long alleles for the DRD4 exon III repeat sequence was associated with psychosis or aggression.
|
9779662 |
1998 |
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The findings are in accordance with our previous report of an association of the DRD4 gene with delusional symptomatology of major psychoses.
|
9754691 |
1998 |
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genotypes of DRD4 polymorphism were analyzed for 47 schizophrenic probands who had at least one living sibling with a diagnosis of schizophrenia, 35 unaffected siblings of the schizophrenic proband, 42 sporadic schizophrenic patients, and 43 healthy controls without a family history of psychosis.
|
9259377 |
1997 |
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The dopamine D4 receptor gene (DRD4 gene) is one of the important candidate genes for schizophrenia and other psychoses.
|
9353244 |
1996 |