DRD4, dopamine receptor D4, 1815

N. diseases: 189; N. variants: 7
Disease: Substance Use Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.030 Biomarker group BEFREE This is the fourth sample that independently associated the DRD2-DRD4 interaction with SUD itself or related disorders. 30367264 2019
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.030 Biomarker group BEFREE The dopamine D4 receptor gene (DRD4) has been implicated in psychiatric disorders in which deficits of self-regulation are a prominent feature (e.g., attention-deficit hyperactivity disorder and substance use disorders) and in dopamine D4 receptor insensitivity within prefrontal regions of the brain. 25107677 2014
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.030 GeneticVariation group BEFREE The goal of this study was to evaluate whether ADHD risk alleles at DRD4 and DAT1 genes could predict the change in striatal DAT occupancy after treatment with MPH in adolescents with ADHD/SUDs. 20593420 2011