DRD4, dopamine receptor D4, 1815

N. diseases: 189; N. variants: 7
Disease: Inattention ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Few DRD4 and SLC6A3 variants showed dichotomous association with IQ and inattention. 31663399 2019
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE ADHD children with DRD4 2-repeat allele have aberrant resting-state within-network connectivity patterns in the left IFG and the right MFG related to dysfunction in inattention symptom. 30050420 2018
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Largely consistent with the hypothesized model, gene-environment interactions indicated that, in the context of insensitive early maternal care, the DRD4 7-repeat polymorphism was associated with higher levels of inattention. 23627945 2013
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Short alleles of the DRD4 and TH repeat polymorphisms were associated with higher levels of activity, impulsivity and inattention. 23713429 2013
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Our findings suggest a contribution of DRD4 7R rare variants to high hyperactivity-inattention scores in a population-based sample from a large birth cohort. 24391992 2013
CUI: C0424101
Disease: Inattention
Inattention 		0.100 Biomarker phenotype BEFREE Additionally, an A-X CPT index of inattention moderated the relation between inattentive ADHD symptoms and DRD4 such that children with high levels of the endophenotype showed a stronger association between inattentive symptoms and DRD4. 22564179 2012
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Homozygosity for the DRD4 promoter 120-bp tandem repeat insertion allele increased vulnerability for ADHD and ODD only in the presence of inconsistent parenting and appeared to increase susceptibility to the influence of increased child self-blame for marital conflict on ADHD inattention. 20644990 2011
CUI: C0424101
Disease: Inattention
Inattention 		0.100 Biomarker phenotype BEFREE Use of symptom scores as continuous scales in regression analysis suggested that the combination of mother and teacher ratings yielded the strongest evidence for association between hyperactive-impulsive ADHD symptoms and DAT1 and between inattentive ADHD symptoms and DRD4. 19025233 2008
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. 17579349 2008
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder. 14560322 2004
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE We observed no significant distortion in the transmission of any of the tested DRD4 variants with inattentive or hyperactive-impulsive subtypes or symptom dimensions. 15389763 2004
CUI: C0424101
Disease: Inattention
Inattention 		0.100 GeneticVariation phenotype BEFREE In analyses of the relation of symptom levels to the DRD4 and DAT1 genotypes, fathers possessing the 7 repeat DRD4 allele had greater levels of both inattention and conduct disorder symptoms. 11443528 2001