DRD4, dopamine receptor D4, 1815

N. diseases: 189; N. variants: 7
Disease: Alcohol problem ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549393
Disease: Alcohol problem
Alcohol problem 		0.010 GeneticVariation phenotype BEFREE Naltrexone reduced percentage drinking days in all participants and reduced percent heavy drinking days in DRD4-L individuals; NTX decreased urge levels in participants with younger age of alcoholism onset; NTX increased time between drinks in participants who had more relatives with alcohol problems; and NTX reduced the stimulating effects of alcohol in women. 18028530 2008