DRD4, dopamine receptor D4, 1815

N. diseases: 189; N. variants: 7
Disease: heavy drinking ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0687132
Disease: heavy drinking
heavy drinking 		0.030 GeneticVariation disease BEFREE Findings provide the first in vivo evidence that, among carriers of the DRD4-L allele, naltrexone blunts craving in real-world settings, and this effect in turn reduces the likelihood of heavy drinking. 29395188 2018
CUI: C0687132
Disease: heavy drinking
heavy drinking 		0.030 GeneticVariation disease BEFREE Regardless of DRD4 genotype, friends' alcohol use at age 17 predicted greater alcohol use and more frequent heavy drinking at age 23. 25457740 2014
CUI: C0687132
Disease: heavy drinking
heavy drinking 		0.030 Biomarker disease BEFREE Multiple regression analyses support the role of NS in mediating the relationship between DRD4 and heavy drinking in male adolescents but not in female adolescents. 16945348 2007