|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Loss of Dsc2 (8/19) and de novo expression of Dsc1 (11/19) and Dsc3 (6/19) was also found in colorectal adenocarcinomas on a background of colitis.
|
17088906 |
2006 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The accuracy of DSC-MR imaging CBV maps in glioblastoma depends on acquisition and analysis protocols.
|
30309842 |
2018 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Analysis of the combined permeability and perfusion metrics obtained from a single DSC-MRI acquisition improves the diagnostic value for differentiating PCNSL from glioblastoma in comparison with single-parameter nCBV analysis.
|
30877463 |
2019 |
|
Adult Oligodendroglioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The DSC-MRI procedure may provide insight into the IDH1/2 mutation and ATRX expression status and MGMT methylation profile of diffuse glioma; however, taking integrated oligodendroglioma into account limits the diagnostic performance of rCBV in non-invasively predicting the molecular subtype.
|
29468261 |
2019 |
|
Alopecia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Autosomal recessive forms of hair loss (alopecia) disorders have previously been associated with variants in at least five different genes including hairless (HR), desmoglein-4 (DSG4), desmocollin-3 (DSC3), lipase-H (LIPH), and lysophosphatidic acid receptor 6 (LPAR6).
|
26148547 |
2015 |
|
Alopecia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recent desmosomal genodermatoses described include lethal congenital epidermolysis bullosa (plakoglobin), cardiomyopathy with alopecia and palmoplantar keratoderma (plakoglobin), hypotrichosis with scalp vesicles (desmocollin 3), and generalized peeling skin disease (corneodesmosin).
|
21929534 |
2012 |
|
ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The DSC-MRI procedure may provide insight into the IDH1/2 mutation and ATRX expression status and MGMT methylation profile of diffuse glioma; however, taking integrated oligodendroglioma into account limits the diagnostic performance of rCBV in non-invasively predicting the molecular subtype.
|
29468261 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we compared cerebral microcirculation in a cohort of AD and mild cognitive impairment (MCI) patients with that of age-matched controls, all without a history of diabetes or of hypertension for more than 2 years, using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI).
|
27951412 |
2017 |
|
Aplasia/Hypoplasia of the eyebrow
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Astrocytoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Noninvasive Assessment of <i>IDH</i> Mutational Status in World Health Organization Grade II and III Astrocytomas Using DWI and DSC-PWI Combined with Conventional MR Imaging.
|
28450436 |
2017 |
|
Astrocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The purpose of our study was to assess the value of dynamic susceptibility contrast MR imaging (DSC-MRI) and diffusion-weighted imaging (DWI) to characterize oligodendrogliomas and to distinguish them from astrocytomas.
|
30712139 |
2019 |
|
Benign cyst of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The positive expression rates of Dsc3 were similar in ovarian cancer tissues (24/31:77.4%) and borderline ovarian tumor tissues (18/22:81.8%) (P>0.05), but were significantly higher in these cancerous tissues than in benign ovarian cyst tissues (3/19:15.8%) (P<0.05).
|
26261554 |
2015 |
|
Borderline ovarian tumour
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The positive expression rates of Dsc3 were similar in ovarian cancer tissues (24/31:77.4%) and borderline ovarian tumor tissues (18/22:81.8%) (P>0.05), but were significantly higher in these cancerous tissues than in benign ovarian cyst tissues (3/19:15.8%) (P<0.05).
|
26261554 |
2015 |
|
Brain Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Based on the retrospective analysis of DSC MRI data from 38 patients with pathology confirmed low (n = 18) and high (n = 20) grade gliomas, the results reveal the spatially defined intra-tumoral hemodynamic heterogeneity of brain tumors based on features of time course profiles.
|
31176951 |
2019 |
|
Brain Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Multisite Concordance of DSC-MRI Analysis for Brain Tumors: Results of a National Cancer Institute Quantitative Imaging Network Collaborative Project.
|
29794239 |
2018 |
|
Brain Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Eighty-three consecutive children with brain tumors underwent DSC perfusion with a standard dose of gadobutrol administered by an automated power injector.
|
30655255 |
2019 |
|
Brain Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The aim of this study was to differentiate hemangioblastomas from metastatic brain tumors using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and compare the diagnostic performances with diffusion-weighted imaging (DWI) and dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI).
|
26952018 |
2017 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters.
|
12789271 |
2003 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Two examples include the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently silenced in this manner in human breast cancer.
|
16799634 |
2007 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
DSC3 expression was downregulated in 23 of 32 (72%) breast cancer specimens comprising: 22 invasive ductal carcinomas, 7 invasive lobular breast carcinomas, 2 invasive ductal carcinomas that metastasized to the lymph node, and a mucoid ductal carcinoma.
|
16168112 |
2005 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Northern analysis, quantitative real-time polymerase chain reaction assay and Western blot analysis showed that desmocollin 3 is present in normal and immortalized human mammary epithelial cells, but consistently exhibits a significant, and often complete, down-regulation in breast cancer cell lines and primary breast tumors, both at the mRNA and protein levels.
|
11408939 |
2001 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Altered expression of desmocollin 3 (DSC3), a member of the desmosomal cadherin family, was found in various cancers; however, its functional involvement in carcinogenesis has not yet been elucidated.
|
22941060 |
2012 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component of desmosomes, is involved in carcinogenesis.
|
21364582 |
2011 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Desmocollin 3 (DSC3) is a transmembrane adhesion protein of desmosomes and involved in carcinogenesis in various cancer types.
|
30857973 |
2019 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of SOX30, DSP, JUP and DSC3 were detected in lung cancer cell lines, lung tissues of mice and patients' tissues by qPCR, WB, Immunofluorescence and Immunohistochemistry.
|
29855376 |
2018 |