|
Hypotrichosis And Recurrent Skin Vesicles
|
0.710 |
GeneticVariation
|
disease |
BEFREE |
A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles.
|
19765682 |
2009 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters.
|
12789271 |
2003 |
|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Northern analysis, quantitative real-time polymerase chain reaction assay and Western blot analysis showed that desmocollin 3 is present in normal and immortalized human mammary epithelial cells, but consistently exhibits a significant, and often complete, down-regulation in breast cancer cell lines and primary breast tumors, both at the mRNA and protein levels.
|
11408939 |
2001 |
|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
DSC3 expression was downregulated in 23 of 32 (72%) breast cancer specimens comprising: 22 invasive ductal carcinomas, 7 invasive lobular breast carcinomas, 2 invasive ductal carcinomas that metastasized to the lymph node, and a mucoid ductal carcinoma.
|
16168112 |
2005 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters.
|
12789271 |
2003 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
DSC3 expression was downregulated in 23 of 32 (72%) breast cancer specimens comprising: 22 invasive ductal carcinomas, 7 invasive lobular breast carcinomas, 2 invasive ductal carcinomas that metastasized to the lymph node, and a mucoid ductal carcinoma.
|
16168112 |
2005 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Northern analysis, quantitative real-time polymerase chain reaction assay and Western blot analysis showed that desmocollin 3 is present in normal and immortalized human mammary epithelial cells, but consistently exhibits a significant, and often complete, down-regulation in breast cancer cell lines and primary breast tumors, both at the mRNA and protein levels.
|
11408939 |
2001 |
|
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
We also used a quantitative real-time RT-PCR approach, and analyzed all breast tumor specimens for DSC3 expression.
|
16168112 |
2005 |
|
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
Northern analysis, quantitative real-time polymerase chain reaction assay and Western blot analysis showed that desmocollin 3 is present in normal and immortalized human mammary epithelial cells, but consistently exhibits a significant, and often complete, down-regulation in breast cancer cell lines and primary breast tumors, both at the mRNA and protein levels.
|
11408939 |
2001 |
|
Hypotrichosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Recent desmosomal genodermatoses described include lethal congenital epidermolysis bullosa (plakoglobin), cardiomyopathy with alopecia and palmoplantar keratoderma (plakoglobin), hypotrichosis with scalp vesicles (desmocollin 3), and generalized peeling skin disease (corneodesmosin).
|
21929534 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of the study was to evaluate usefulness of multiparametric T2*DSC perfusion and diffusion MR imaging in the preoperative differentiation of these tumors.
|
29342201 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor rCBV estimates were obtained using DSC T2* perfusion analysis.
|
31134296 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggested that DSC3 acts as a novel tumor suppressor gene through inhibition of epidermal growth factor receptor/extracellular signal-regulated kinase signaling in lung cancer cells.
|
22941060 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using an ecotropic transfection system, empty vector (pLXSN) or EphB4 (EphB4<sup>OE</sup>) overexpressing Phoenix-ECO cells were coimplanted with SF126 glioma cells subcutaneously (dorsal skinfold chamber, DSC) and orthotopically (cranial window, CW).Tumor volume was assessed by MRI.
|
29987450 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A high segmentation accuracy comparable to interrater variability was achieved for the whole tumor (mean dice similarity coefficient [DSC], 0.86 ± 0.09) and CE tumor (DSC, 0.78 ± 0.15).
|
29863600 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesize that acantholysis-induced epidermal hyperplasia in the Dsc3 null epidermis facilitates Ras-induced tumor development.
|
21681825 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Non-invasive diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) are widely used to provide physiological information (cellularity, hemorrhage, calcifications, and angiogenesis) of neoplastic histology and tumor grade.
|
28474187 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the new method can potentially extract more tumor physiological information from DSC MRI comparing to the traditional model-based analysis and morphological analysis of tumor heterogeneity, thus may improve the characterizations of gliomas for better diagnosis and treatment decisions.
|
31176951 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.
|
30857973 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of the present study was to compare different software algorithms for processing DSC perfusion images of cerebral tumors with respect to i) the relative CBV (rCBV) calculated, ii) the cutoff value for discriminating low- and high-grade gliomas, and iii) the diagnostic performance for differentiating these tumors.
|
27646457 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Developmental Venous Anomalies Mimicking Neoplasm on 11C-Methionine PET and DSC Perfusion MRI.
|
28319499 |
2017 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
DTI metrics (<i>p</i>:<i>q</i> tensor decomposition) and DSC perfusion demonstrated a statistically significant difference in the mean values of ADC, the isotropic component of the diffusion tensor, the anisotropic component of the diffusion tensor, the total magnitude of the diffusion tensor, and rCBV among enhancing portions in tumefactive demyelinating lesions and high-grade gliomas (<i>P</i> ≤ .02), with the highest specificity for ADC, the anisotropic component of the diffusion tensor, and relative CBV (92.9%).
|
28209583 |
2017 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
To assess the diagnostic performance of dynamic susceptibility contrast perfusion magnetic resonance perfusion imaging (DSC-MRI) for in vivo human glioma molecular profiling.
|
29468261 |
2019 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Eligible studies reported on patients evaluated with relative maximal CBV derived from DSC with a confirmed neuropathologic diagnosis of glioma World Health Organization grades II and III.
|
28522666 |
2017 |
|
Glioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We retrospectively reviewed 16 patients who had DSC MRI and molecular studies of their excised gliomas for 1p19q deletions.
|
17520715 |
2007 |