|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization.
|
8034325 |
1994 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal desmogleins with molecular weights of 130/140 kDa (Dsg3 or PVA) and 150/160 kDa (Dsg1 or DGI) are recognized by autoantibodies from patients with pemphigus vulgaris (PV) and pemphigus foliaceus (PF), respectively.
|
7547386 |
1995 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that both pemphigus foliaceus and pemphigus vulgaris sera react with conformationally sensitive epitopes in the amino-terminal region of Dsg1.
|
7543545 |
1995 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune skin diseases caused by autoantibodies against desmoglein (Dsg) 3 and Dsg1, respectively.
|
9257868 |
1997 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is a dermatosis characterized by subcorneal vesicles and pathogenic IgG autoantibodies against desmoglein 1.
|
9325073 |
1997 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively.
|
10551416 |
1999 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice.
|
11120754 |
2000 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have analysed the characteristics of the 'pockets' of the susceptibility-associated molecules to PV and PF and we showed that (i) in PV, two kinds of Dsg3 derived peptides may be presented by HLA-DR according to HLA polymorphism (DRB1*0402 or DRB1*14/0406), (ii) the same Dsg1 peptides may be presented by DRB1*0102, DQB1*0404 or DRB1*14 in PF, (iii) the DRB1*14/0406 PV-related molecules may be able to present Dsg1 and Dsg3 peptides thereby providing an explanation for the cases of PV with combined responses to Dsg1 and to Dsg3 which are typified by a muco-cutaneous clinical phenotype.
|
10936030 |
2000 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphic variant of the gene coding desmoglein 1, the target autoantigen of pemphigus foliaceus, is associated with the disease.
|
11294567 |
2001 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, some sera of Brazilian PF patients or cases with mixed features of PV and PF also reacted with the intracellular domains of Dsg1 or Dsg3.
|
11154866 |
2001 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herewith, we report, based on a case-control analysis, that the same DSG1 polymorphism participates in susceptibility to the endemic form of PF seen in Tunisia and, thus, show that common genetic factors govern the breakage of tolerance to desmoglein 1 in different epidemiological and environmental situations.
|
12209366 |
2002 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combined analysis of HLA class II and DSG1 polymorphisms with several distinct statistical methods including logistic regression, showed that the DRB1*04 allele and the C/C(809) genotype interact to confer a higher susceptibility to PF.
|
12058255 |
2002 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus is an autoimmune blistering skin disease characterized by intraepidermal blisters and circulating autoantibodies directed against desmoglein 1, a 160 kDa transmembrane desmosomal molecule expressed in keratinocytes.
|
12190860 |
2002 |
|
Pemphigus Foliaceus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF), in which autoantibodies bind, respectively, to desmoglein 3 and desmoglein 1, are strongly associated with HLA-class II DR4 and DR14 alleles.
|
12604316 |
2003 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
This recombinant canine Dsg1 produced by baculovirus shares the major epitopes of the authentic canine Dsg1 recognized by human PF sera, and will be useful in studying the molecular pathophysiological mechanisms in PF and impetigo in canine patients.
|
12963278 |
2003 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that genetic diversity of the autoantigen dsg1 is not a major factor for PF pathogenesis in the Brazilian population.
|
16242304 |
2005 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In particular, involvement of a polymorphic variant of desmoglein 1 gene was shown to be associated with pemphigus foliaceus and to interact in an epistatic manner with MHC class II genes to contribute to the autoimmune process.
|
15869862 |
2005 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two Dsg are targeted by pathogenic autoantibodies produced in the course of autoimmune bullous skin diseases, Dsg1 in pemphigus foliaceus (PF), and Dsg3 and Dsg1 in pemphigus vulgaris.
|
17056584 |
2006 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes.
|
16611260 |
2006 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We provide evidence that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were equally effective in causing epidermal splitting in human skin and keratinocyte dissociation in vitro.
|
17640963 |
2007 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dsg1 is the target autoantigen of pathogenic autoantibodies produced by pemphigus foliaceus and 50% of pemphigus vulgaris patients in a Dsg1-specific T-cell-dependent pathway.
|
18331528 |
2008 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Desmoglein 3 is targeted in pemphigus vulgaris while desmoglein 1 is targeted in pemphigus foliaceus and its endemic form, Fogo Selvagem.
|
18838249 |
2008 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These mAbs will be useful for studying Dsg1 function and mechanisms of blister formation in PF and for developing targeted therapies and tools to monitor disease activity.
|
18007588 |
2008 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following the candidate gene approach we analyzed the CD40L, CD40, BLYS and CD19 genes that participate of B-cell co-stimulation, for association with pemphigus foliaceus (PF), an organ-specific autoimmune disease, characterized by the detachment of epidermal cells from each other (acantholysis) and presence of autoantibodies specific for desmoglein 1 (dsg1), an epidermal cell-adhesion molecule.
|
19421221 |
2009 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-desmoglein 1 antibodies in healthy related and unrelated subjects and patients with pemphigus foliaceus in endemic and non-endemic areas from Tunisia.
|
19453789 |
2009 |