|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dsg1 reactivity was detected in 9/21 PV (sensitivity 42.8%), 2/13 m-PV (sensitivity 15,4%), 7/8 mc-PV (sensitivity 87.5%) and 13/14 PF (sensitivity 92.9%).
|
30910537 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus is an autoimmune bullous disease with autoantibodies against desmoglein 1.
|
31335412 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF) patients present autoantibodies against Dsg1.
|
31178865 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is an autoimmune blistering skin disease characterized by the presence of bullous skin lesions, the absence of mucous tissue involvement, and the production of auto-antibodies directed against a keratinocyte transmembrane protein localized in the desmosome and member of the cadherines, desmoglein 1.
|
30577075 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1.
|
30884100 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is an epidermal autoimmune disease, characterized by the presence of autoantibodies against the desmosomal protein desmoglein 1.
|
30653253 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously we have shown that PF IgG induces aggregation of DSG1, plakoglobin (PG), and IgG outside of desmosomes, what in immunofluorescence of PF patient skin visualizes as a granular IgG deposition pattern with a limited number of coarse IgG aggregates between cells.
|
31781120 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies directed against desmoglein-1 located in the upper epidermal layer.
|
30474029 |
2018 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is a rare autoimmune skin disease caused by anti-Dsg1 pathogenic autoantibodies.
|
30116153 |
2018 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Erythroderma is a severe manifestation of pemphigus foliaceus (PF), a blistering disease mediated by IgG autoantibodies against desmoglein 1.
|
29489039 |
2018 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reactivity mainly against Dsg1 suggests that PH in south Tunisia is a particular variant of nonendemic pemphigus foliaceus.
|
30011065 |
2018 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The endemic form (fogo selvagem-FS) of pemphigus foliaceus is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-1.
|
28855908 |
2017 |
|
Pemphigus Foliaceus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IgG against the SGEs from S. nigrimanum and N. neivai but not against the SGE from A. aegypti correlated with levels of anti-Desmoglein 1 in PF patients (r=0.3848, P=0.039; and r=0.416, P=0.022, respectively).
|
28941730 |
2017 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to the desmosomal proteins desmoglein 1 and 3 cause pemphigus foliaceus and pemphigus vulgaris, which are characterised by keratinocyte dissociation (acantholysis) and intraepidermal blister formation.
|
28211055 |
2017 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate how pathogenic and non-pathogenic anti-Dsg1 Abs contribute to blister formation in PF.
|
28024684 |
2017 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1.
|
26597100 |
2016 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is a complex autoimmune disease characterized by bullous skin lesions and the presence of antibodies against desmoglein 1.
|
24813052 |
2014 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS).
|
22810308 |
2012 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The clinical and histological similarities of staphylococcal scalded skin syndrome or bullous impetigo and pemphigus foliaceus led us to identify desmoglein 1 as the proteolytic target of staphylococcal exfoliative toxins.
|
22189787 |
2012 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, the younger sister with PV developed PF with only anti-Dsg1 antibody detected.
|
21352303 |
2011 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) is a multifactorial autoimmune blistering disease characterized by keratinocyte detachment and by autoantibodies against desmoglein 1, a desmosomal protein.
|
20433886 |
2010 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against Dsg 3 and/or Dsg 1 could be detected in 71 (100%) of 71 PV sera and against Dsg 1 in 48 (96%) of 50 PF sera.
|
20163452 |
2010 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following the candidate gene approach we analyzed the CD40L, CD40, BLYS and CD19 genes that participate of B-cell co-stimulation, for association with pemphigus foliaceus (PF), an organ-specific autoimmune disease, characterized by the detachment of epidermal cells from each other (acantholysis) and presence of autoantibodies specific for desmoglein 1 (dsg1), an epidermal cell-adhesion molecule.
|
19421221 |
2009 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-desmoglein 1 antibodies in healthy related and unrelated subjects and patients with pemphigus foliaceus in endemic and non-endemic areas from Tunisia.
|
19453789 |
2009 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, presentation of peptides from Dsg1 by preDsg1-specific B cells may be one step in developing autoimmunity in PF.
|
19843946 |
2009 |