Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Many studies have investigated the association between angiotensinogen gene M235T polymorphism and MI risk, but the results were inconsistent.
|
23666149 |
2013 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991.
|
21167013 |
2012 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Excessive activation of the β-adrenergic, angiotensin II (Ang II) and aldosterone signaling pathways promotes mortality after myocardial infarction, and antagonists targeting these pathways are core therapies for treating this condition.
|
22081025 |
2011 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease.
|
20945963 |
2011 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study investigated whether variation in the genes encoding for ACE, AGT and AGTR1 modifies the risk of myocardial infarction (MI) related to ACE inhibitors and AT II antagonists.
|
21163865 |
2011 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI.
|
20529973 |
2010 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke.
|
17299437 |
2007 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To assess the association of the angiotensin II type 2 (AT2) receptor (-1332 G/A) gene polymorphism with premature coronary artery disease (CAD) and investigate for a further role in both myocardial infarction and predominantly stenotic atherosclerosis requiring revascularisation.
|
17336987 |
2007 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke.
|
17299437 |
2007 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined frequencies of the M235T variant of angiotensinogen gene and I/D polymorphism of gene for angiotensin-converting enzyme in Slovak population: in hypertensive patients, coronary heart disease (CHD), dilated cardiomyopathy (DCM) and myocardial infarction (MI) patients compared to healthy subjects.
|
17579251 |
2007 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the independent contribution of the angiotensinogen M235T mutation to the development of recurrent coronary events (coronary-related death, nonfatal myocardial infarction, or unstable angina) in a cohort of 916 black (n=145) and white (n=771) postmyocardial infarction patients who were prospectively studied during an average follow-up of 28 months.
|
16940224 |
2006 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Regulation of cardiac and renal mineralocorticoid receptor expression by captopril following myocardial infarction in rats.
|
16413583 |
2006 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of haplotypes formed by these polymorphisms for angiotensinogen levels we examined blood pressure, coronary artery disease (CAD), myocardial infarction (MI), and AGT genotypes and haplotypes in 2,575 patients with angiographically documented CAD and 731 individuals in whom CAD had been ruled out by angiography.
|
15599691 |
2005 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Myocardial connective tissue growth factor (CTGF) mRNA and protein expressions were increased by 300% in dTGR (P < 0.05), especially in areas with myocardial infarctions and vascular inflammation.
|
15662226 |
2005 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers.
|
14502296 |
2003 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that risk of stroke or myocardial infarction (MI) associated with ACE inhibitor use varies by AGT genotype, with a larger protective effect of ACE inhibitors in individuals with the ThrThr genotype than individuals who are carriers of the Met allele.
|
14643574 |
2003 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction.
|
12444540 |
2002 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The angiotensin II type 2 (AT2) receptor is thought to play a role in cardiovascular disorders such as neointima formation after vascular injury, cardiac hypertrophy and myocardial infarction (MI).
|
12453540 |
2002 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings may reflect the relative lack of importance of the I/D polymorphism and ACE activity in determining plasma and tissue angiotensin II concentration after a major stimulus to the renin-angiotensin system as occurs after myocardial infarction.
|
12102452 |
2002 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Efficacy of angiotensin II type 1 receptor blockade on reperfusion-induced arrhythmias and mortality early after myocardial infarction is increased in transgenic rats with cardiac angiotensin II type 1 overexpression.
|
11904535 |
2002 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the authors provide evidence of an interactive effect on MI risk between risk genotypes of RAS, as well as between the angiotensinogen-TT genotype and metabolic risk factors.
|
11330506 |
2001 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Both alleles of the M235T polymorphism of the angiotensinogen gene can be a risk factor for myocardial infarction.
|
11531970 |
2001 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction.
|
11137090 |
2001 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
AGT 235 T homozygous patients with multivessel CAD have an increased risk of myocardial infarction as compared with subjects with clinically similar phenotype but different genotype.
|
11393670 |
2001 |