DSG3, desmoglein 3, 1830

N. diseases: 78; N. variants: 0
Disease: Polycythemia Vera ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera 		0.020 Biomarker disease BEFREE However, additional incubation with PV-IgG was effective to promote Dsg3 loss at the membrane, indicating that Dsg3 internalization is independent from keratin alterations. 29922278 2018
CUI: C0032463
Disease: Polycythemia Vera
Polycythemia Vera 		0.020 Biomarker disease BEFREE Together, these results indicate that a single potent Dsg3-reactive T cell is sufficient to commit polyclonal naive B cells to produce pathogenic anti-Dsg3 IgG Abs and induce the PV phenotype. 19155523 2009