Compared with cisplatin and platinum(iv) (DSP), the Gd2(WO4)3@SiO2 nanoparticles functionalized with DSP (Gd2(WO4)3@SiO2-Pt-PEG) exert higher lethality against CT26 cells and significantly inhibit the growth of tumors at the same concentration of Pt.
<i>In vivo</i> phototherapy indicated that DPP-NF NPs exhibited excellent tumor phototherapeutic efficacy with passive targeting of the tumor site <i>via</i> the enhanced permeability and retention (EPR) effect.
In addition, recent pre-clinical trials indicate dipeptidyl peptidase (DPP) enzyme inhibition, an enzyme that can regulate immune cell trafficking to the tumour microenvironment, as a novel cancer therapy.
We determined recently that dentin sialophosphoprotein (DSPP), a member of the SIBLING (Small integrin-binding ligand N-linked glycoproteins) family of phosphoglycoproteins, is highly upregulated in human oral squamous cell carcinomas (OSCCs) where upregulation is associated with tumor aggressiveness.