Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
AT1R blockade is beneficial only when the AT1R was overexpressed, both in reducing the reperfusion-induced arrhythmias and mortality early after MI.
|
11904535 |
2002 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
AGTR1 polymorphism has been reported to associate with hypertension, myocardial infarction (MI), and metabolic traits.
|
17211857 |
2007 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction.
|
9298740 |
1997 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported.
|
11137090 |
2001 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
RGD |
Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats.
|
9652322 |
1998 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, the relationship between AT1R polymorphism and biventricular function in acute anterior MI has not been studied before.
|
16998258 |
2006 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Among men and women the odds ratio for MI for AT1R (CC vs. AC + AA) was 1.02 (0.71, 1.47).
|
11122322 |
2000 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
An interactive effect on MI risk was found between ACE-DD and AGT1R-AA genotypes (odds ratio [OR]=2, 95% CI= 1-3.9), between ACE-DD and angiotensinogen-TT genotypes (OR = 2.7, 95% CI = 1-7.3), as well as among ACE-DD, angiotensinogen-TT, and AGT1R-AA genotypes (OR=4.8, 95% CI = 1-22.8).
|
11330506 |
2001 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
LHGDN |
Angiotensin receptor blockers may increase risk of myocardial infarction: unraveling the ARB-MI paradox.
|
16923768 |
2006 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations.
|
23178513 |
2014 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, the present study suggests that AT1R-810 T/A, or other polymorphisms which are in complete association with it, might be associated with the risk of myocardial infarction.
|
9814614 |
1998 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
I/D polymorphism and angiotensin II type 1 receptor genotypes did not relate individually to risk of myocardial infarction or atheroma in univariate or multivariate analysis.
|
10435047 |
1999 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ratio = 1.13 per allele, p = 0.005).
|
17293603 |
2007 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ratio = 1.13 per allele, p = 0.005).
|
17293603 |
2007 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inhibition of the brain renin-angiotensin system by oral APA inhibitor is at least as effective as oral AT1R blocker to inhibit cardiac dysfunction after MI but without hypotension or renal dysfunction.
|
30531435 |
2019 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting.
|
11393670 |
2001 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Myocardial AT1 receptor density increases in association with ACE expression, and AT1 receptor activation is related to collagen formation following myocardial infarction in rats.
|
9796075 |
1998 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that common genetic variations in the AGTR1 gene may affect the risk of MI in Chinese males, and that there might be several functional variants in AGTR1 gene and the combined effect of these variants seemed to have a larger effect on the risk of MI in Chinese males.
|
15454732 |
2004 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the AT1 gene have been associated with various parameters related to the pathogenesis of cardiovascular diseases and to myocardial infarction.
|
20537563 |
2011 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Subjects carrying the ACE DD genotype and AT1R C allele showed a stronger association with myocardial infarction (OR=4.02, P<0.0001).
|
10731400 |
2000 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies.
|
12460700 |
2002 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.
|
19713412 |
2009 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The AT1R CC genotype conferred a 2.76-fold higher risk of MI compared with the genotype AC and AA.
|
24167376 |
2013 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The authors conducted a population-based, case-control study at Group Health (Seattle, Washington) between 1995 and 1999 to determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angiotensin-converting enzyme gene, and the angiotensin II receptor type 1 and receptor type 2 genes were associated with the risk of myocardial infarction and stroke among pharmacologically treated hypertensive patients.
|
17522061 |
2007 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R.
|
30050591 |
2018 |