Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE But whether Dyrk1A could rescue lysosome malfunction-mediated DA neuron death and α-synuclein aggregation in PD is still unknown. 30904670 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 AlteredExpression disease BEFREE The mRNA and protein levels of DYRK1A were increased in SH-SY5Y dopaminergic cells expressing miR-204-5p and SN of MPTP-induced PD mouse model. 31572127 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 GeneticVariation disease BEFREE We found that the APOE ε4 allele is associated with a higher risk for PD-D. Gene-gene interaction analysis revealed that three significant gene-gene interactions, including BDNF and CLU, APOE and CR1, and DYRK1A and CD2AP increase the risk for PD. 29698690 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 GeneticVariation disease BEFREE These results suggest that TT genotype derived from SNP rs8126696 of DYRK1A gene is a possible risk factor for sporadic PD, especially for males in this Chinese Han population. 27546826 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE This is the first report of significant associations of DYRK1A and MS4A6A SNPs and the AAO of PD. 27085534 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. 24922073 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE To determine if DYRK1A also has a genetic association with α-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. 22269890 2012