Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We determined the presence of the R219K variant in the ABCA1 gene by polymerase chain reaction (PCR) and restriction analysis in 301 patients with and without CAD.
|
20303467 |
2010 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of ATP-binding cassette transporter A1 gene polymorphisms with plasma lipid variability and coronary heart disease risk.
|
26722555 |
2015 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of four polymorphisms in the ABCA1 gene (G1051A, G2706A, G2868A and -565C/T) with lipid profile and coronary artery disease.
|
21130966 |
2010 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia.
|
12700893 |
2003 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The R219K polymorphism on ATP-binding cassette transporter A1 gene is associated with coronary heart disease risk in Asia population: evidence from a meta-analysis.
|
25104170 |
2015 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 variants rs2230806 (rs2230806" genes_norm="19">R219K), rs4149313 (M8831I), and rs9282541 (rs9282541" genes_norm="19">R230C) are associated with susceptibility to coronary heart disease.
|
31006134 |
2019 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CETP rs5882 (OR = 1.45, P < 0.005) and ABCA1 rs2230806 (OR = 1.42, P = 0.017) polymorphisms were associated with increased risk of CAD.
|
26936456 |
2016 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We explored if polymorphisms in the ABCA1 gene are associated with CAD and variations in plasma lipid levels, especially HDL-C, and whether the associations may depend on ethnicity.
|
12709788 |
2003 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Novel polypyrimidine variation (IVS46: del T -39...-46) in ABCA1 causes exon skipping and contributes to HDL cholesterol deficiency in a family with premature coronary disease.
|
14576201 |
2003 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease.
|
21643759 |
2012 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The carriers of allele 219K were found to have a lower risk of CAD than the non-carriers: OR=0.76, 95% CI=0.68-0.85, P=3.78E-07, P(heterogeneity)=3.59E-08; meanwhile, 18 studies from 17 papers with 12,869 subjects were included in the association between the ABCA1 R219K polymorphism and the level of HDL-C.
|
21310416 |
2011 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A point mutation in ABC1 gene in a patient with severe premature coronary heart disease and mild clinical phenotype of Tangier disease.
|
11257260 |
2001 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, common genetic variations of ABCA1 had a moderate influence on HDL-C levels and/or coronary heart disease in patients with T2D.These 2 effects were independent.
|
19059534 |
2009 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 gene polymorphisms but not haplotypes are involved in the variability of plasma ApoA1 and the susceptibility to coronary artery disease.
|
14962947 |
2004 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several studies have investigated the influence of ABCA1 variation on lipid metabolism and coronary heart disease, but they have resulted in controversial and inconsistent results.
|
18706283 |
2008 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop).
|
15657615 |
2005 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined common promoter and non-synonymous coding polymorphisms in relation to age of symptom onset in a group of CAD patients (n = 1164), and also carried out in vitro assays to test effects of the promoter variations on ABCA1 promoter transcriptional activity and effects of the coding variations on ABCA1 function in mediating cellular cholesterol efflux.
|
17412755 |
2007 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease.
|
11257261 |
2001 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
On a background of contemporary secondary prevention, variation in the ABCA1 promoter influences 10-year risk of vascular death and angiographic extent of CAD in men.
|
21840005 |
2011 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 rs4149313 polymorphism and susceptibility to coronary heart disease: a meta-analysis.
|
24942079 |
2014 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The role of ABCA1 C69T and G-191C gene polymorphisms on plasma lipid levels of patients with coronary artery disease was investigated.
|
18468402 |
2008 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
|
11940086 |
2002 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in ABCA1, as seen in Tangier disease, result in accumulation of cellular cholesterol, reduced plasma high-density lipoprotein cholesterol, and increased risk for coronary artery disease.
|
16704350 |
2006 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the ATP-binding cassette transporter 1 gene with decreased HDL-cholesterol levels and coronary artery disease.
|
18996286 |
2008 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, variants in ATP-binding cassette transporter A1 (ABCA1) were demonstrated to be associated with increased level of high density lipoprotein cholesterol (HDL-C) and decreased risk of coronary artery disease (CAD) in Caucasians.
|
12860256 |
2003 |