|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
|
11940086 |
2002 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ATP-binding cassette transporter A1 locus is not a major determinant of HDL-C levels in a population at high risk for coronary heart disease.
|
12535741 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 gene polymorphisms but not haplotypes are involved in the variability of plasma ApoA1 and the susceptibility to coronary artery disease.
|
14962947 |
2004 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
ABCA1 gene was initially implicated in Tangier disease and familial hypoalphalipoproteinemia and has been shown to be associated with coronary artery disease and atherosclerosis as well.
|
16009332 |
2005 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
ABCA1 predicted HDL (mean, GG = 36.4 mg/dL, AA = 39.2 mg/dL; P = .02) but not CAD (GG 74%, AA 75%; adjusted P = .96, OR = 0.99).
|
16086925 |
2005 |
|
Coronary Artery Disease
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
ABCA1 DNA methylation levels were also found associated with prior history of CAD (CAD = 40.2% vs. without CAD = 34.3%; p = 0.003).
|
22419126 |
2012 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 rs4149313 polymorphism and susceptibility to coronary heart disease: a meta-analysis.
|
24942079 |
2014 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ABCA1 variants rs2230806 (rs2230806" genes_norm="19">R219K), rs4149313 (M8831I), and rs9282541 (rs9282541" genes_norm="19">R230C) are associated with susceptibility to coronary heart disease.
|
31006134 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia.
|
12624133 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.
|
20595220 |
2011 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A point mutation in ABC1 gene in a patient with severe premature coronary heart disease and mild clinical phenotype of Tangier disease.
|
11257260 |
2001 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among polymorphisms in ATP-binding cassette transporter A1 (ABCA1) gene, the available evidence demonstrates that the ABCA1 R219K polymorphism (G1051A, rs2230806) K allele is associated with a higher high-density lipoprotein cholesterol (HDL- C) level and may play a protective role against coronary artery disease (CAD) risk in Asians and Caucasians.
|
25877294 |
2015 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the ABCA1-565C/T gene promoter polymorphism and coronary heart disease severity and cholesterol efflux in the Chinese Han population.
|
26090796 |
2015 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of ATP-binding cassette transporter A1 gene polymorphisms with plasma lipid variability and coronary heart disease risk.
|
26722555 |
2015 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CETP rs5882 (OR = 1.45, P < 0.005) and ABCA1 rs2230806 (OR = 1.42, P = 0.017) polymorphisms were associated with increased risk of CAD.
|
26936456 |
2016 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the ATP-binding cassette transporter 1 gene with decreased HDL-cholesterol levels and coronary artery disease.
|
18996286 |
2008 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease.
|
11257261 |
2001 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Each 8% change in ABCA1-mediated efflux is predicted to be associated with a 0.1 mmol/l change in HDL-C. ABCA1 heterozygotes display a greater than threefold increase in the frequency of coronary artery disease (CAD), with earlier onset than unaffected family members.
|
11086027 |
2000 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease.
|
19673941 |
2009 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease.
|
27560308 |
2016 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, only mutation carriers with HDLc <5th percentile had elevated risk of CAD (odds ratio (OR)=2.26 for 34 ABCA1 mutation carriers vs. 149 total first-degree relative controls, p=0.05; OR=2.50 for 26 APOA1 mutation carriers, p=0.04; OR=3.44 for 38 LCAT mutation carriers, p=1.1∗10(-3)).
|
21875686 |
2012 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation of the ATP-binding cassette transporter A1 and susceptibility to coronary heart disease.
|
21300560 |
2011 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.
|
15528481 |
2005 |
|
Coronary Artery Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of the low-density lipoprotein receptor and ATP-binding cassette transporter A1 was markedly increased, indicating that the beneficial effect of statins in allergic asthma and coronary artery disease was mediated, at least in part, by decreasing cholesterol biosynthesis and foam cell formation.
|
31558320 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |