|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
To study the location and expression of receptors (SR-BI/CLA-1, SR-BII, and LDLr) and transporter (ABCA1) involved in uptake and efflux of cholesterol in human spermatozoa and assess whether obesity alters its location/expression and whether this could be related to infertility.
|
30659447 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Specifically, mimicking miR-758-3p in HepG2 cells suppressed cholesterol efflux regulatory protein/ATP-binding cassette transporter protein expression; conversely, inhibiting miR-758-3p increased cholesterol efflux regulatory protein/ATP-binding cassette transporter protein expression. miR-758-3p holds potential as a blood-based biomarker for distinguishing progression from obesity to metabolic syndrome and as a driver in controlling cholesterol efflux regulatory protein/ATP-binding cassette transporter expression, indicating it potential role in cholesterol control in metabolic syndrome.
|
29507696 |
2018 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The genotypic frequency of rs2275542 also differed between the control group and case group (p < 0.05); (2) rs2515602, rs2230806, and rs4149313 polymorphisms were significantly related to risk of overweight/obese; (3) a significant linkage disequilibrium (LD) was observed between the ABCA1 gene rs2275542 with rs3890182 and rs2515602 with rs4149313.
|
26891315 |
2016 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.
|
26828509 |
2016 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Novel association of the R230C variant of the ABCA1 gene with high triglyceride levels and low high-density lipoprotein cholesterol levels in Mexican school-age children with high prevalence of obesity.
|
26256050 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Thus, we aimed to investigate the association between ABCA1 gene polymorphisms and overweight/obesity risk, and to evaluate their relation to the lipid profile.
|
26243156 |
2015 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Current data exclude a major function of these syntrophins in ABCA1 activity and insulin release but suggest a role in regulating glucose uptake, ERK and SR-BI levels, and sphingomyelin metabolism in obesity.
|
25625330 |
2015 |
|
Obesity
|
0.300 |
ModifyingMutation
|
disease |
RGD |
Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition.
|
25612518 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
LCAT mass showed a tendency to reduction in MetS (p = 0.08), and inversely correlated with ABCA1-cholesterol efflux (r = -0.51; p = 0.001), independently of obesity and insulin-resistance (β = -0.40, p = 0.034).
|
26232163 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, investigation on HDL metabolism in obesity with a particular emphasis on hepatic ATP-binding cassette transporter A1 (ABCA1), the primary factor for HDL formation, has not been well studied.
|
21574779 |
2011 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos.
|
18003760 |
2008 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Although the lower level of HDL in overweight/obese men carrying R219K in comparison to the control suggests the possible involvement of this gene with obesity, further investigations are needed to prove the influence of ABCA1 gene polymorphism on HDL level and to determine whether it could be a genetic determinant of obesity.
|
17923263 |
2007 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This is the first study reporting the association of an ABCA1 variant with obesity and obesity-related comorbidities as being epidemiologically relevant in the Mexican population.
|
17287470 |
2007 |