ABCA1, ATP binding cassette subfamily A member 1, 19

N. diseases: 291; N. variants: 116
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE The main factors associated with IR were body fat percentage and triglycerides; SNP for the ABCA1 gene was related to MS, obesity and low HDL-C; SNP for GCKR gene was related to high fasting glycemia, while APOAV SNP was related with MS, hypertriglyceridemia and low HDL-C. Our findings show that the Mexican genetic predisposition to NCD affects young adults, who can suffer MS, obesity and IR. 31796261 2020
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE The aim of our work was to assess total and plasma membrane expressions of cholesterol transport proteins: adipocyte ATP-binding cassette A1 (ABCA1), adipocyte ATP-binding cassette G1 (ABCG1), class B scavenger receptor (SR-BI) in visceral and subcutaneous adipose tissue of obese subjects with and without metabolic syndrome. 31172973 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE Specifically, mimicking miR-758-3p in HepG2 cells suppressed cholesterol efflux regulatory protein/ATP-binding cassette transporter protein expression; conversely, inhibiting miR-758-3p increased cholesterol efflux regulatory protein/ATP-binding cassette transporter protein expression. miR-758-3p holds potential as a blood-based biomarker for distinguishing progression from obesity to metabolic syndrome and as a driver in controlling cholesterol efflux regulatory protein/ATP-binding cassette transporter expression, indicating it potential role in cholesterol control in metabolic syndrome. 29507696 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE We identified the NF-κB target miR-9-5p as a negative regulator of ABCA1 adding a novel target pathway in the relationship between inflammation and HDL-driven reverse cholesterol transport for prevention or treatment of atherosclerosis in MS. 29584810 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population. 30382898 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE It also examines their influence in the modulation of plasma membrane lipid composition and in the functionality of membrane proteins involved in insulin activity, like the insulin receptor, GLUT-4, CD36/FAT and ABCA-1, and their effect in the metabolism of glucose, fatty acids and cholesterol, and, in turn, the key features of the metabolic syndrome. 28428072 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE The R230C variant of the ABCA1 gene was genotyped to seek associations with MetS and other metabolic traits. 26256050 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE Regardless the reduced HDL-cholesterol, in vitro cholesterol efflux capacity by ABCA1 was enhanced, linked to increased pre-β1-HDL and slightly reduced in LCAT mass that would probably reflect a delay in reverse cholesterol transport occurring in MetS. 26232163 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE We further sought to determine whether egg yolk intake affects peripheral blood mononuclear cell (PBMC) inflammation and cholesterol homeostasis in MetS, as HDL and its associated lipid transporter ATP-binding cassette transporter A1 (ABCA1) reduce the inflammatory potential of leukocytes through modulation of cellular cholesterol content and distribution. 25045936 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE Metabolites elevated in individuals with the metabolic syndrome and diabetes destabilize ABCA1 protein and decrease cholesterol export from macrophages, raising the possibility that an impaired ABCA1 pathway contributes to the enhanced atherogenesis associated with common inflammatory and metabolic disorders. 19344785 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. 18003760 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker disease BEFREE Metabolites elevated in individuals with the metabolic syndrome and diabetes destabilize ABCA1 protein and decrease cholesterol export from macrophages. 16183915 2005