|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p = .06).
|
31543086 |
2020 |
|
Sphingolipidoses
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We discuss (a) the role of the nuclear receptors DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human adrenal and reproductive dysfunction; (b) multisystem growth restriction syndromes due to gain-of-function in the growth repressors CDKN1C (IMAGE syndrome) and SAMD9 (MIRAGE syndrome), or loss of POLE1; (c) nonclassic forms of STAR and P450scc/CYP11A1 insufficiency that present with a delayed-onset adrenal phenotype and represent a surprisingly prevalent cause of undiagnosed PAI; and (d) a new sphingolipidosis causing PAI due to defects in sphingosine-1-phosphate lyase-1 (SGPL1).
|
31610036 |
2020 |
|
MIRAGE SYNDROME
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We discuss (a) the role of the nuclear receptors DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human adrenal and reproductive dysfunction; (b) multisystem growth restriction syndromes due to gain-of-function in the growth repressors CDKN1C (IMAGE syndrome) and SAMD9 (MIRAGE syndrome), or loss of POLE1; (c) nonclassic forms of STAR and P450scc/CYP11A1 insufficiency that present with a delayed-onset adrenal phenotype and represent a surprisingly prevalent cause of undiagnosed PAI; and (d) a new sphingolipidosis causing PAI due to defects in sphingosine-1-phosphate lyase-1 (SGPL1).
|
31610036 |
2020 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both poorer DSS performance and the presence of perseveration can offer useful clinical information on the context of a thorough evaluation of the aMCI/DAT spectrum.
|
30931811 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that genetic deletion of CARD9 was sufficient to reduce the development of both spontaneous autoimmune disease as well as DSS- or IL-10 deficiency-associated colitis in <i>Lyn<sup>-/-</sup></i> mice.
|
31594855 |
2019 |
|
Adenomatous Polyposis Coli
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Triptolide reduced both tumor number and tumor size in adenomatous polyposis coli (Apc) mutated (Apc<sup>Min/+</sup>) mice as well as AOM/DSS-induced mice.
|
31122284 |
2019 |
|
Teratoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two sisters phenotypically normal females, presenting with tumor abdominal mass with histopathological findings of teratoma and gonadoblastoma associated to 46,XY male-to-female sex reversal syndrome, secondary to a duplication in DAX-1, possibly inherited of maternal gonadal mosaicism.
|
30879272 |
2019 |
|
Gestational Diabetes
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Rates of gestational diabetes mellitus (GDM) (P = 0.007) and female neonates (P = 0.001) were significantly higher in the LHG group compared with the HHG group; no significant differences were observed in the low versus high HCG group overall.
|
30660603 |
2019 |
|
Addisonian crisis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Background X-linked adrenal hypoplasia congenita (AHC), due to mutations in the nuclear receptor superfamily 0, group B, member 1 (NR0B1)/dosage-sensitive sex reversal, AHC, critical region on the X chromosome, gene 1 (DAX1) gene, usually presents with a salt-wasting adrenal crisis in infancy and hypogonadotropic hypogonadism (HH) in adolescents.
|
31219797 |
2019 |
|
Gonadoblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two sisters phenotypically normal females, presenting with tumor abdominal mass with histopathological findings of teratoma and gonadoblastoma associated to 46,XY male-to-female sex reversal syndrome, secondary to a duplication in DAX-1, possibly inherited of maternal gonadal mosaicism.
|
30879272 |
2019 |
|
Differentiated Thyroid Gland Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although extent of thyroidectomy does not affect DSS, total thyroidectomy is beneficial for reducing recurrence in patients with 1-cm to 4-cm DTC.
|
30536465 |
2019 |
|
Adult Teratoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two sisters phenotypically normal females, presenting with tumor abdominal mass with histopathological findings of teratoma and gonadoblastoma associated to 46,XY male-to-female sex reversal syndrome, secondary to a duplication in DAX-1, possibly inherited of maternal gonadal mosaicism.
|
30879272 |
2019 |
|
Childhood Teratoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two sisters phenotypically normal females, presenting with tumor abdominal mass with histopathological findings of teratoma and gonadoblastoma associated to 46,XY male-to-female sex reversal syndrome, secondary to a duplication in DAX-1, possibly inherited of maternal gonadal mosaicism.
|
30879272 |
2019 |
|
Chronic ulcerative colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate whether ATX-LPA axis contributes to Th17 cell differentiation, a mouse model of chronic UC was established by drinking water with DSS at intervals.
|
31102124 |
2019 |
|
Intestinal fibrosis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We demonstrate reduced intestinal fibrosis in mice deficient for the CH25H enzyme, using the sodium dextran sulphate [DSS]-induced chronic colitis model.
|
31220227 |
2019 |
|
Primary differentiated carcinoma of thyroid gland
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although extent of thyroidectomy does not affect DSS, total thyroidectomy is beneficial for reducing recurrence in patients with 1-cm to 4-cm DTC.
|
30536465 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DAX1 expressed a gradual increase from normal cervix to high-grade squamous intraepithelial lesions, and consequently to cervical cancer.
|
29497051 |
2018 |
|
Gastrointestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Methods:</b> Two established models of experimental colitis, namely chemically-induced DSS colitis and the spontaneous colitis that develops in <i>Muc2</i> deficient mice, were used to assess whether QBECO treatment could ameliorate gastrointestinal disease.
|
30319652 |
2018 |
|
Intestinal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Application of the AOM-DSS protocol for induction of colitis-associated CRC resulted in increased intestinal tumor load in male but not in female STAT1<sup>∆IEC</sup> mice.
|
29419930 |
2018 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Besides their central role in physiology, NRs have been largely used as therapeutic drug targets in many chronic inflammatory conditions and derivatives of their specific ligands, alone or in combination, are frequently prescribed for the treatment of skin diseases.
|
29966221 |
2018 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
It also downregulated the expression of NF-κB-related proteins, including the B-cell lymphoma 2 (Bcl-2) family and inhibitors of apoptosis proteins (IAPs), in mice with AOM/DSS-induced CAC.
|
29439531 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Electronic databases (up to June 7, 2018) were comprehensively searched to collect relevant cohort studies regarding the associations between NNMT expression levels and survival outcomes (overall survival [OS], disease-specific survival [DSS] including cancer-specific survival [CSS], and time to tumor progression [TTP] including disease-free survival [DFS], progression-free survival [PFS], and metastasis-free survival [MeFS]).Publication biases were also examined.
|
30349486 |
2018 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients ≥ 60 years of age have worse DSS and DFS after a diagnosis of PTC, across all stages of disease.
|
29566662 |
2018 |
|
Chronic colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
For the initiation of fibrosis in vivo, spontaneous colitis by Il10-/-, dextran sodium sulfate [DSS]-induced chronic colitis and the heterotopic intestinal transplantation model were used.
|
30165600 |
2018 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DAX1 expressed a gradual increase from normal cervix to high-grade squamous intraepithelial lesions, and consequently to cervical cancer.
|
29497051 |
2018 |