|
High-Grade Squamous Intraepithelial Lesions
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
DAX1 expressed a gradual increase from normal cervix to high-grade squamous intraepithelial lesions, and consequently to cervical cancer.
|
29497051 |
2018 |
|
Sentinel node (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
When patients with a positive SLN receive additional treatment to the at-risk nodal basin, both OS and DSS are similar to patients with a negative SLN.
|
29549898 |
2018 |
|
Acute colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pathologically, Erbin expression in the intestinal mucosa was significantly decreased in DSS induced acute colitis mice, IL-10 deficient mice and clinical biopsy specimens from patients with ulcerative colitis.
|
29552291 |
2018 |
|
Solitary Pulmonary Nodule
|
0.010 |
Biomarker
|
disease |
BEFREE |
DSS and OS of pancreatic head SPNs (HOP) were significantly shorter than those of other locations (OOP).
|
30057602 |
2018 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DAX1 expressed a gradual increase from normal cervix to high-grade squamous intraepithelial lesions, and consequently to cervical cancer.
|
29497051 |
2018 |
|
Trauma symptoms
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Questionnaires measuring trauma symptoms (HTQ), quality of life (WHO-5), dissociative symptoms (SDQ-20, DSS-20) and adult attachment (RAAS) are applied, as well as physiological measures (salivary oxytocin, beta-endorphin and substance P) and participant evaluation of each session.
|
29848343 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Atherosclerosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days and continued on HFD for another 10 weeks.
|
28638138 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Atherosclerosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days and continued on HFD for another 10 weeks.
|
28638138 |
2017 |
|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the treatment outcomes among patients with T1aN0 laryngeal cancer with laryngectomy-free disease-specific survival (LFS-DSS), which is defined as time to total laryngectomy or time to death from cancer cause, against all other endpoints.
|
27778345 |
2017 |
|
Hyperinsulinism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In isolated primary Leydig cells from rats, BDE47 or insulin increased DAX-1 expression, decreased the expression of StAR and 3β-HSD, and reduced testosterone production, which was nearly reversed by knocking down DAX-1.
|
28300557 |
2017 |
|
Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DSS among all the hr-HPV+ patients was 78 % in the first period versus 77 % in the second period, while the OS was 71 versus 69 %, respectively.
|
27491318 |
2017 |
|
Situs Inversus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dextran sulfate sodium (DSS-exposure) is an established animal model for experimental colitis that was recently shown to recapitulate the link between GI-tract damage and pathogenic features of SIV infection.
|
28687795 |
2017 |
|
Malignant neoplasm of oropharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of note, OS and DSS of the patients with p16-negative OPC and heterozygous ALDH2 was significant poorer than those of the patients with p16-positive OPC (p = 0.002, 0.006, respectively), while there was no significant difference in OS and DSS between patients with p16-positive OPC and patients with p16-negative OPC and homozygous ALDH2.
|
29206831 |
2017 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analyses showed patients with ILC had a higher risk of liver metastasis (disease-specific survival[DSS]; P = 0.046), but had a better overall survival than the bone metastasis group (P<0.0001).
|
28863134 |
2017 |
|
Carcinoma, Lobular
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Survival analyses showed patients with ILC had a higher risk of liver metastasis (disease-specific survival[DSS]; P = 0.046), but had a better overall survival than the bone metastasis group (P<0.0001).
|
28863134 |
2017 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings designate NR0B1 as a druggable transcriptional regulator that supports NRF2-dependent lung cancers.
|
28965760 |
2017 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, we undertook a pan-cancer analyses of the nuclear hormone receptor (NR) superfamily in The Cancer Genome Atlas (TCGA), and revealed that the vitamin D receptor (NR1I1/VDR) was commonly and significantly down-regulated specifically in colon adenocarcinoma cohort (COAD).
|
28027912 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High Ki-67 expression in localized PCa is a factor of poor prognosis for DSS, biochemical failure-free survival, DFS, DM, and OS after curative-intent treatments.
|
28648414 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Survival analyses showed patients with ILC had a higher risk of liver metastasis (disease-specific survival[DSS]; P = 0.046), but had a better overall survival than the bone metastasis group (P<0.0001).
|
28863134 |
2017 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the treatment outcomes among patients with T1aN0 laryngeal cancer with laryngectomy-free disease-specific survival (LFS-DSS), which is defined as time to total laryngectomy or time to death from cancer cause, against all other endpoints.
|
27778345 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High Ki-67 expression in localized PCa is a factor of poor prognosis for DSS, biochemical failure-free survival, DFS, DM, and OS after curative-intent treatments.
|
28648414 |
2017 |
|
Chromosome 11p11.2 Deletion Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Smooth muscle cell migration was arrested in both the DSS and PSS-treated groups compared to that in the nontreated group (4.2% ± 0.31, 5.8% ± 0.60, 80.0% ± 4.4, respectively, n = 10, p < 0.05).
|
27615559 |
2017 |
|
PEELING SKIN SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
Smooth muscle cell migration was arrested in both the DSS and PSS-treated groups compared to that in the nontreated group (4.2% ± 0.31, 5.8% ± 0.60, 80.0% ± 4.4, respectively, n = 10, p < 0.05).
|
27615559 |
2017 |
|
Oropharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of note, OS and DSS of the patients with p16-negative OPC and heterozygous ALDH2 was significant poorer than those of the patients with p16-positive OPC (p = 0.002, 0.006, respectively), while there was no significant difference in OS and DSS between patients with p16-positive OPC and patients with p16-negative OPC and homozygous ALDH2.
|
29206831 |
2017 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
DSS colitis phenotype was more severe in the ileocolic resection groups and this was associated with local and systemic immunosuppression as evidenced by a reduced cytokine responses to microbial stimuli.
|
28922370 |
2017 |