S1PR1, sphingosine-1-phosphate receptor 1, 1901

N. diseases: 126; N. variants: 6
Disease: Atherosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE Rapamycin may also stabilize artery plaques by preventing apoptosis and S1PR1 in advanced atherosclerosis. 30627532 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE S1PR1-targeting compounds significantly reduce lesion size in murine models of AS. 29134505 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE Our data suggests that sphingosine-1-phosphate receptor 1 in macrophages plays an important role in protecting them against apoptosis in vitro and in atherosclerotic plaques in vivo, and delays diet induced atherosclerosis development in <i>Ldlr</i> deficient mice. 29244772 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE Endothelial cell-specific deletion of S1pr1 in the hypercholesterolemic Apoe(-/-) mouse model of atherosclerosis enhanced atherosclerotic lesion formation in the descending aorta. 26268607 2015