|
Auriculo-condylar syndrome
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears.
|
24268655 |
2013 |
|
Auriculocondylar syndrome 1
|
0.610 |
GeneticVariation
|
disease |
BEFREE |
Auriculocondylar syndrome and isolated question mark ear result from dysregulation of the endothelin 1-endothelin receptor type A signaling pathway.
|
28456137 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was performed to study the genetic association between DR and polymorphic variants of EDN1 (Lys198Asn), LTA (IVS1-80C>A, IVS1-206G>C, IVS1-252A>G), eNOS (Glu298Asp), and ITGA2 (BgI II) in a Chinese population with type 2 diabetes mellitus.
|
18806884 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The object of the study was to investigate the share of the polymorphisms I/D ACE, endothelin 1 4127G/A and TNF-beta NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin-dependent diabetes mellitus (NIDDM).
|
11399938 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
PCR primers for highly polymorphic sites within the EDN1 and NOS3 genes were used to genotype individuals with type 1 or type 2 diabetes with severe or no retinopathy.
|
10450377 |
1999 |
|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lower risk for heart failure with higher ET1 levels could not be clearly shown in a model including health behaviors.
|
31515065 |
2020 |
|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A common endothelin-1 gene haplotype may be a pharmacogenetic predictor of a favorable clinical response to beta-blocker therapy in heart failure patients.
|
18953265 |
2009 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A common endothelin-1 gene haplotype may be a pharmacogenetic predictor of a favorable clinical response to beta-blocker therapy in heart failure patients.
|
18953265 |
2009 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients.
|
18923236 |
2008 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The second objective is to find an association between polymorphisms G8002A and -3A/4A EDN-1 with diabetes mellitus (DM), peripheral artery disease (PAD) and myocardial infarction (MI) in patients with chronic heart failure (CHF).
|
18442814 |
2008 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The double heterozygote variants of two ET-1 gene polymorphisms were associated with significantly less risk for chronic heart failure with higher levels of big endothelin.
|
12565798 |
2002 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lower risk for heart failure with higher ET1 levels could not be clearly shown in a model including health behaviors.
|
31515065 |
2020 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth.
|
15505112 |
2004 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The endothelin-1 G5665T single nucleotide polymorphism has been linked to increased vascular reactivity and hypertension.
|
18603063 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The associations of the 5-HT2A T102C polymorphism with hypertension and diastolic blood pressure in ET-1 T allele carriers were significant (p = 0.0056 and 0.021, respectively).
|
16778329 |
2006 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.
|
18288492 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The purpose of this study was to investigate the role of endothelin-1 Lys198Asn polymorphism in patients with severe arterial hypertension as well as associated endorgan damages.
|
18923236 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We assessed the correlation of 10 single-nucleotide polymorphisms (SNPs) in genes modulating angiogenesis (vascular endothelial growth factor-A (VEGF-A), VEGF receptor 1 (VEGFR-1), serine threonine kinase 39 (STK39)) or hypertension (endothelin-1 and uromodulin) with outcome and toxicity.
|
27139155 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Endothelin-1 gene and endothelial nitric oxide synthase gene polymorphisms in adolescents with juvenile and obesity-associated hypertension.
|
17444275 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A gene polymorphism in EDN1, Lys198Asn, has been reported to be associated with hypertension in obese subjects.
|
17664854 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Recently, two single nucleotide polymorphisms in EDN1 have been reported to be associated with hypertension: Lys198Asn and 3A/4A (-134delA) located in the 5'-untranslated region.
|
28692114 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results indicated that the mechanisms of hypertension in AMA may differ from those in young individuals from the point of VEGF-endothelin-1 system.
|
31272714 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We searched for EDN1 variants in 145 Spanish patients with an essential form of LVH (not secondary to hypertension, aortic stenosis, or any other disease that could explain the hypertrophy).
|
17335511 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Moreover, in line with previous reports, this study revealed a significant interaction between the ET-1 K198N (G/T) polymorphism and BMI in association with hypertension in our populations (P=0.027).
|
12511547 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The Lys198Asn polymorphism of the endothelin-1 gene has been associated with increased blood pressure levels in several studies involving European and Australian adults.
|
12963677 |
2003 |