|
Carotid Artery Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of ET-1 and ET<sub>B</sub> receptors was increased in plaques from patients with symptomatic carotid artery disease.
|
31606133 |
2020 |
|
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 has been studied as a predictor of and prognostic marker in coronary artery disease, myocardial infarction, and heart failure.
|
30765295 |
2020 |
|
Mirror syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, we elucidated a temporal spectrum of maternal serum mediators (soluble Flt-1, endothelin-1, 8-isoprostane, activin-A, ICAM-1, and vWF) involved in the pathogenesis of Mirror syndrome.
|
30614331 |
2020 |
|
Heart failure with normal ejection fraction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelin 1 Is Associated with Heart Failure Hospitalization and Long-Term Mortality in Patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension.
|
31514181 |
2020 |
|
Angina Pectoris
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MATERIAL AND METHODS To evaluate the effects of angina pectoris, the differences of scores of the Seattle angina questionnaire (SAQ), vascular endothelial function [endothelial progenitor cells (EPCs), nitric oxide (NO) and endothelin 1 (ET-1)], and inflammatory factors [tumor necrosis factor a (TNF-α), hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6)] in 2 groups were assessed before and after treatment.
|
30636768 |
2019 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelin-1-mediated cerebral ischemia in mice: early cellular events and the role of caspase-3.
|
31073782 |
2019 |
|
Dyspnea
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In patients with an acute onset of dyspnoea after 48 h, a decrease of N-terminal pro BNP was more frequently observed (83% vs. 65%), and the levels of endothelin-1 were more reduced [-1.1 (-2.9-0.03) vs 0.4 (-2.2-1.4); all P < 0.05].
|
30426729 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the current study, the cardiovascular effects of ET-1 and big endothelin-1 (big-ET-1) administered systemically or intrathecally were assessed in the early preclinical phase of EAE in telemetry instrumented/conscious mice.
|
31248979 |
2019 |
|
Fibromuscular Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene.
|
30621952 |
2019 |
|
Giant Cell Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
To examine the role of endothelin-1 (ET-1) and the Notch signaling pathway in giant cell tumor (GCT) of the spine.
|
30921293 |
2019 |
|
Hepatic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of hepatic encephalopathy correlated inversely with RBCA and directly with IL-6 and endothelin-1.
|
30920976 |
2019 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, the pathological glomerular endothelial cell lesions were associated with FPW and the VEGF-endothelin-1 system might play a critical role in the endothelial cell-podocyte crosstalk in LN.
|
30755145 |
2019 |
|
Obesity, Morbid
|
0.010 |
Biomarker
|
disease |
BEFREE |
To date, one of the best treatments available for morbid obesity is bariatric surgery to quickly reduce body fat and the factors associated with obesity-related disease; however, the effects of vertical sleeve gastrectomy (SG) on plasma ET-1 have not been described.
|
31147283 |
2019 |
|
Ocular Hypotension
|
0.010 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve analysis showed that ET-1 concentration in aqueous humor was a predictor for late low IOP after trabeculectomy with an area under the curve of 0.639, a specificity of 84.62%, and a sensitivity of 39.89%, respectively (P=0.006).
|
30950963 |
2019 |
|
Optic Neuritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Severity and failure in the recovery from ON in MS patients may depend from vascular hypoperfusion of the optic nerve induced by high intrathecally produced ET-1, a potential prognostic marker of ON recovery in MS.
|
31583031 |
2019 |
|
Osteosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 may be a paracrine factor responsible for increased bone formation and osteosclerosis.
|
31079185 |
2019 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions.
|
30925731 |
2019 |
|
Ovarian Hyperstimulation Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
According to these results, celecoxib significantly decreased VEGF, IL-2, and ET-1 levels as much as cabergoline and could reduce the extent of OHSS development.
|
31040646 |
2019 |
|
Hypertensive Retinopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression models indicated that hypertension duration (P<0.001, 95% CI: 0.962-0.988) and ET-1 level (P<0.001, 95% CI: 1.144-1.278) were significantly associated with HRP.
|
30651821 |
2019 |
|
Gastrointestinal Carcinoid Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GCT stromal cells (GCTSCs) were isolated and ET-1 expression was demonstrated by immunofluorescence.
|
30921293 |
2019 |
|
Memory impairment
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We have previously demonstrated that overexpression of astrocytic ET-1 exacerbates memory deficits in aged mice or in APP<sup>K670/M671</sup> mutant mice.
|
31248984 |
2019 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Compared to the control, placental vascular contractile responses to angiotensin II and caffeine were significantly decreased, while placental vascular responses to KCl, endothelin-1, and bradykinin were not significantly altered in the later term preeclampsia.
|
31845629 |
2019 |
|
Iron deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
While retaining normal systemic iron levels, this model developed PAH and right heart failure as a consequence of intracellular iron deficiency and increased expression of the vasoconstrictor endothelin-1 (ET-1) within PASMCs.PAH was prevented and reversed by i.v. iron and by the ET receptor antagonist BQ-123.
|
31152133 |
2019 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
A number of vasoactive mediators including proprotein convertase subtilisin-kexin type 9 (PCSK9), endothelin-1, nitric oxide, and angiotensin II have fundamental roles in the pathophysiology of atherosclerotic events; moreover, their levels are affected by dyslipidemia and oxidative stress due to renal dysfunction.
|
31641998 |
2019 |
|
Thickening of pleura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions.
|
30925731 |
2019 |