|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we found that the expression of ET-1 and VEGF were correlated with tumor stage and were significantly higher than that in the normal cartilage.
|
23584483 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Endothelin-1 (ET-1) is a hormone peptide widely expressed and is involved in several biological processes, important not only for normal cell function but also for tumor development, including cell proliferation, invasion, metastasis, angiogenesis and osteogenesis.
|
28092772 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results provide mechanistic insight into how ET-1R coopts β-catenin signaling and offer a novel therapeutic strategy to manage CRC based on the combination of macitentan and chemotherapy that might benefit patients whose tumors show high ET<sub>A</sub>R and β-catenin expression.
|
28708138 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings demonstrate that ET-1-driven autocrine loop is crucial for enhanced invasiveness of KS IMM cells and promote tumor growth in vivo.
|
12875994 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Levels of endothelin-1 (ET-1), a potent vasoconstrictor, were affected by both RhoGDI2 reconstitution and tumor stage.
|
16103083 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) signalling is linked to many tumor promoting effects, such as proliferation, angiogenesis, invasion and metastasis.
|
24530737 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ETAR expression as well as ET-1 expression was associated with vascular invasion and tumor stage in HCC.
|
26501871 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The endothelin-1 (ET-1) axis contributes to the pathophysiology of several cancers by promoting tumor development and progression.
|
30926432 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and renal diseases, and in the progression of tumour growth in cancer, but current diagnosis and treatment remain inadequate.
|
28694457 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Endothelin-1 (ET-1) and its receptors (ETAR and ETBR), referred to as the endothelin (ET) axis, are overexpressed in breast carcinomas and appear to influence tumour growth and progression.
|
15226779 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The contribution of the endothelin-1 (ET-1)/ET A receptor (ETAR) axis in tumor growth and progression is investigated in many tumor types, including ovarian carcinoma.
|
20725137 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using human and mouse cancer cells depleted of ET-1 and pharmacologic blockade of ET receptors in lung metastasis models, we found that tumor ET-1 expression and ETAR activity are necessary for metastatic lung colonization and that this process is preceded by and dependent on macrophage infiltration of the lung.
|
21183790 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated whether ET-1 stimulated processes involved in tumour stroma production by colonic fibroblasts.
|
21445967 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The experimental data indicated that ET-1 silencing can inhibit tumor cell proliferation and invasion, particularly in the presence of Endostar.
|
28599441 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found a highly positive correlation between ET-1 and Twist expression levels as well as tumor stage in chondrosarcoma patient specimens.
|
27602960 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Endothelin-1 is a powerful mitogen for various tumor and non-tumor cells.
|
18457675 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We show that the ppET1-targeted vector is efficacious for therapeutic gene expression in vivo, validating a strategy targeted to tumour vasculature, and demonstrate that vascular targeting combined with appropriate chemotherapy is more effective than either therapy alone.
|
15543524 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A decrease in BC cell adhesion and tumor growth in vivo following PFN downregulation are observed, likely associated with the concomitant downregulation of Fibronectin receptor, Endothelin-1, and Actin polymerization.
|
27683119 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We show that SOX4 directly regulates endothelin-1 (ET-1) expression and can thereby promote tumor-induced angiogenesis both in vitro and in vivo.
|
30507376 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This suggests that blockage of ET-1 production may suppress tumor growth and possibly metastasis.
|
9809984 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these data provide mechanistic insight into the action of CPT in ccRCC, identify ET-1 as a p53-regulated gene and demonstrate a requirement of mTOR for p53-mediated responses in this tumor type.
|
24136229 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that GPER may contribute to ET-1 action toward the progression of some types of tumor.
|
26607335 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As ET1-ETA receptor signaling was upregulated in a variety of tumors, this strategy might open a new avenue for tumor treatment.
|
29274786 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, the expression of endothelin-1 and endothelin receptors was studied in eight human tumour cell lines: T98G (glioblastoma), IMR-32 and NB69 (neuroblastoma), BeWo (choriocarcinoma), SW-13 (adrenocortical carcinoma), DLD-1 (colonic carcinoma), HeLa (cervical carcinoma) and VMRC-RCW (renal carcinoma).
|
12193050 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In striking contrast, 100% of moderately to highly pigmented invasive melanomas contained numerous ET-1-positive cells in the tumor microenvironment, with 79% containing ET-1-positive melanoma cells, confirmed by co-staining with melanoma tumor marker HMB45.
|
26825037 |
2016 |