|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The endothelin-1 (ET-1) axis contributes to the pathophysiology of several cancers by promoting tumor development and progression.
|
30926432 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We show that SOX4 directly regulates endothelin-1 (ET-1) expression and can thereby promote tumor-induced angiogenesis both in vitro and in vivo.
|
30507376 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As ET1-ETA receptor signaling was upregulated in a variety of tumors, this strategy might open a new avenue for tumor treatment.
|
29274786 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The treatment with the ET-1R antagonist macitentan impairs the interaction of β-arr1 with hMENA and inhibits invadopodial maturation and tumor dissemination in SOC orthotopic xenografts.
|
29439204 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Endothelin-1 (ET-1) is a hormone peptide widely expressed and is involved in several biological processes, important not only for normal cell function but also for tumor development, including cell proliferation, invasion, metastasis, angiogenesis and osteogenesis.
|
28092772 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results provide mechanistic insight into how ET-1R coopts β-catenin signaling and offer a novel therapeutic strategy to manage CRC based on the combination of macitentan and chemotherapy that might benefit patients whose tumors show high ET<sub>A</sub>R and β-catenin expression.
|
28708138 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and renal diseases, and in the progression of tumour growth in cancer, but current diagnosis and treatment remain inadequate.
|
28694457 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The experimental data indicated that ET-1 silencing can inhibit tumor cell proliferation and invasion, particularly in the presence of Endostar.
|
28599441 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ETAR expression as well as ET-1 expression was associated with vascular invasion and tumor stage in HCC.
|
26501871 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found a highly positive correlation between ET-1 and Twist expression levels as well as tumor stage in chondrosarcoma patient specimens.
|
27602960 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A decrease in BC cell adhesion and tumor growth in vivo following PFN downregulation are observed, likely associated with the concomitant downregulation of Fibronectin receptor, Endothelin-1, and Actin polymerization.
|
27683119 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that GPER may contribute to ET-1 action toward the progression of some types of tumor.
|
26607335 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In striking contrast, 100% of moderately to highly pigmented invasive melanomas contained numerous ET-1-positive cells in the tumor microenvironment, with 79% containing ET-1-positive melanoma cells, confirmed by co-staining with melanoma tumor marker HMB45.
|
26825037 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor specimens after initial transurethral resection were stained immunohistochemically for ET-1.
|
25627007 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we found that the expression of ET-1 and VEGF were correlated with tumor stage and were significantly higher than that in the normal cartilage.
|
23584483 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) signalling is linked to many tumor promoting effects, such as proliferation, angiogenesis, invasion and metastasis.
|
24530737 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The endothelin-1 (ET-1)/endothelin A receptor (ETAR, a G protein-coupled receptor) axis confers pleiotropic effects on both tumor cells and the tumor microenvironment, modulating chemo-resistance and other tumor-associated processes by activating Gαq- and β-arrestin-mediated pathways.
|
25194819 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these data provide mechanistic insight into the action of CPT in ccRCC, identify ET-1 as a p53-regulated gene and demonstrate a requirement of mTOR for p53-mediated responses in this tumor type.
|
24136229 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated whether ET-1 stimulated processes involved in tumour stroma production by colonic fibroblasts.
|
21445967 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent experiments demonstrate that the ET-1 axis exerts a potent antiapoptotic effect involving sphingolipid metabolism and prostaglandin-endoperoxide synthase 2/prostaglandin system in the rat Eker leiomyoma tumor-derived ELT3 cell line.
|
22553222 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using human and mouse cancer cells depleted of ET-1 and pharmacologic blockade of ET receptors in lung metastasis models, we found that tumor ET-1 expression and ETAR activity are necessary for metastatic lung colonization and that this process is preceded by and dependent on macrophage infiltration of the lung.
|
21183790 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The contribution of the endothelin-1 (ET-1)/ET A receptor (ETAR) axis in tumor growth and progression is investigated in many tumor types, including ovarian carcinoma.
|
20725137 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The candidate genes located at amplified regions of chromosomes or low-level gain regions such as PLA2G5 (1p36-p34), COL11A1 (1p21), KCNK2 (1q41), S100A3 (1q21), ENAH (1q42.12), RGS1 (1q31), KCNH1 (1q32-q41), INSIG2 (2q14.1), FGF12 (3q28), TRIO (5p15.2), RNASEN (5p15.2), FGF10 (5p13-p12), EDN1(6p24.1-p22.3), SULF1 (8q13.2-13.3), TLR4 (9q32-q33), TNC (9q33), NTRK2 (9q22.1), CD44 (11p13), NCAM1 (11q23.1), TRIM29 (11q22-q23), PAK1 (11q13-q14) and RAB27A (15q15-q21.1), are found to be associated with cellular migration and proliferation, tumor cell metastasis and invasion, anchorage independent growth and inhibition of apoptosis.
|
20083228 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Proteins of the ET axis were frequently expressed in bladder cancer (ET-1 in 62% of tumours, ET(A)R in 93% of tumours, and ET(B)R in 84% of tumours).
|
18945538 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Endothelin-1 is a powerful mitogen for various tumor and non-tumor cells.
|
18457675 |
2008 |