EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Disease: Kidney Failure, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.250 GeneticVariation disease BEFREE EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients. 28882114 2017
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.250 AlteredExpression disease BEFREE Expression of endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the development of acute and chronic renal disease. 25572710 2015
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.250 GeneticVariation disease BEFREE Recent studies have reported that EDN1 and EDNRA polymorphisms can influence the age of onset of end-stage renal disease in ADPKD. 21894000 2011
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.250 GeneticVariation disease BEFREE We examined the influence of three single-nucleotide polymorphisms of the ET-1 gene (EDN1)--K198N, 3A/4A, and T-1370G--on the progression of ADPKD towards end-stage renal disease (ESRD). 16943682 2006
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.250 GeneticVariation disease BEFREE We evaluated the role of the neuronal constitutive (NOS1) and endothelial constitutive (NOS3) nitric oxide synthase genes and the endothelin-1 (EDN-1) gene in predisposition to chronic renal failure in African-Americans. 11071967 2000
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.250 Biomarker disease RGD Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. 8441230 1993