Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, preclinical and, more recently, clinical evidence both point to this G protein-coupled receptor as a target of interest in the treatment of not only cardiovascular disorders such as heart failure, pulmonary arterial hypertension, atherosclerosis, or septic shock, but also of additional conditions such as water retention/hyponatremic disorders, type 2 diabetes, and preeclampsia.
|
31236974 |
2019 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased abundance of GRK2 [G protein-coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients.
|
30538174 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
G protein-coupled receptor (GPCR) kinase-2 (GRK2) is a regulator of GPCRs, in particular β-adrenergic receptors (ARs), and as demonstrated by decades of investigation, it has a pivotal role in the development and progression of cardiovascular disease, like heart failure (HF).
|
29166798 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overstimulation of the sympathetic nervous system is an adaptive neurohormonal response to acute myocardial injury and heart damage, whereas prolonged exposure to catecholamines causes defects in βAR regulation, including a reduction in the amount of βARs and an increase in βAR desensitization due to the upregulation of G protein-coupled receptor kinases (GRKs) in the heart, contributing in turn to the progression of HF.
|
30538631 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased G protein-coupled receptor kinase (GRK)2 is central to heart failure (HF) pathogenesis, via desensitization of β-adrenergic receptors and loss of contractile reserve.
|
30171848 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeting a G protein-coupled receptor in cardiomyocytes offers protection in a mouse model of cardiac failure.
|
28698218 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure.
|
27297948 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A meta-analysis reveals that the ETA receptor regulation in human heart failure appears to depend on non-failing hearts.
|
28095452 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
CTD_human |
A meta-analysis reveals that the ETA receptor regulation in human heart failure appears to depend on non-failing hearts.
|
28095452 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Down-regulation and desensitization of β-adrenergic receptors (β-AR) caused by G-protein-coupled receptor (GPCR) kinase 2 (GRK2) are prominent features of HF.
|
24702056 |
2014 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
One of the striking characteristics of HF is the desensitization of G protein-coupled receptor (GPCR) signaling, particularly the beta-adrenergic receptor (betaAR) system.
|
21622221 |
2011 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we included four G-protein-coupled receptor (GPCR)-encoding genes, three enzyme-encoding genes, and one ion-channel protein-encoding gene to identify a drug target for heart failure using in silico microarray database.
|
20100464 |
2010 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ET-1 Lys198Asn and ET(A) receptor H323H polymorphisms seem to act synergistically to increase the risk of HF.
|
16582543 |
2006 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.
|
16501306 |
2006 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
G-protein-coupled receptor kinases (GRKs) are implicated in the pathophysiology of human diseases such as arterial hypertension, heart failure and rheumatoid arthritis.
|
15225142 |
2004 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries.
|
14729387 |
2004 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
1.Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure.
|
11906480 |
2002 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variant in the Exon 8 of the endothelin receptor type A gene appears as a genetic risk factor for idiopathic forms of heart failure.
|
10529327 |
1999 |