|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Molecular signaling of G-protein-coupled receptor in chronic heart failure and associated complications.
|
31785110 |
2020 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, preclinical and, more recently, clinical evidence both point to this G protein-coupled receptor as a target of interest in the treatment of not only cardiovascular disorders such as heart failure, pulmonary arterial hypertension, atherosclerosis, or septic shock, but also of additional conditions such as water retention/hyponatremic disorders, type 2 diabetes, and preeclampsia.
|
31236974 |
2019 |
|
Congestive heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overstimulation of the sympathetic nervous system is an adaptive neurohormonal response to acute myocardial injury and heart damage, whereas prolonged exposure to catecholamines causes defects in βAR regulation, including a reduction in the amount of βARs and an increase in βAR desensitization due to the upregulation of G protein-coupled receptor kinases (GRKs) in the heart, contributing in turn to the progression of HF.
|
30538631 |
2018 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased G protein-coupled receptor kinase (GRK)2 is central to heart failure (HF) pathogenesis, via desensitization of β-adrenergic receptors and loss of contractile reserve.
|
30171848 |
2018 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
G protein-coupled receptor (GPCR) kinase-2 (GRK2) is a regulator of GPCRs, in particular β-adrenergic receptors (ARs), and as demonstrated by decades of investigation, it has a pivotal role in the development and progression of cardiovascular disease, like heart failure (HF).
|
29166798 |
2018 |
|
Congestive heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased abundance of GRK2 [G protein-coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients.
|
30538174 |
2018 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeting a G protein-coupled receptor in cardiomyocytes offers protection in a mouse model of cardiac failure.
|
28698218 |
2017 |
|
Congestive heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A meta-analysis reveals that the ETA receptor regulation in human heart failure appears to depend on non-failing hearts.
|
28095452 |
2017 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
CTD_human |
A meta-analysis reveals that the ETA receptor regulation in human heart failure appears to depend on non-failing hearts.
|
28095452 |
2017 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure.
|
27297948 |
2017 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Down-regulation and desensitization of β-adrenergic receptors (β-AR) caused by G-protein-coupled receptor (GPCR) kinase 2 (GRK2) are prominent features of HF.
|
24702056 |
2014 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
One of the striking characteristics of HF is the desensitization of G protein-coupled receptor (GPCR) signaling, particularly the beta-adrenergic receptor (betaAR) system.
|
21622221 |
2011 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we included four G-protein-coupled receptor (GPCR)-encoding genes, three enzyme-encoding genes, and one ion-channel protein-encoding gene to identify a drug target for heart failure using in silico microarray database.
|
20100464 |
2010 |
|
Congestive heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ET-1 Lys198Asn and ET(A) receptor H323H polymorphisms seem to act synergistically to increase the risk of HF.
|
16582543 |
2006 |
|
Congestive heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA).
|
16501306 |
2006 |
|
Congestive heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
G-protein-coupled receptor kinases (GRKs) are implicated in the pathophysiology of human diseases such as arterial hypertension, heart failure and rheumatoid arthritis.
|
15225142 |
2004 |
|
Congestive heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
1.Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure.
|
11906480 |
2002 |
|
Congestive heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variant in the Exon 8 of the endothelin receptor type A gene appears as a genetic risk factor for idiopathic forms of heart failure.
|
10529327 |
1999 |