|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene amplification results in the enhancement in the level of the EGF receptor in several carcinomas and could be responsible for the appearance of the transformed phenotype in these cells.
|
2984254 |
1985 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Southern blot-hybridization analysis of DNAs from human tumors demonstrated amplification of the epidermal growth factor (EGF) receptor gene in 10 of 12 squamous cell carcinoma cell lines tested and in none of 18 tumor cell lines of nonsquamous cell carcinomas.
|
2998610 |
1986 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have examined a group of ten human tumors including cervical, ovarian, and vulval carcinomas for expression of EGF receptors by immunohistological staining using one of these antibodies and another monoclonal antibody to the extracellular domain of the molecule.
|
2998607 |
1986 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To ascertain the possible autocrine pathway in the growth promotion of gastric carcinomas, a study was made on the effects of exogenous human epidermal growth factor (hEGF) on the expression of mRNA for EGF, transforming growth factor-a (TGF-a), EGF receptor, FOS and MYC genes by TMK-1 cells.
|
2511181 |
1989 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These results strongly suggest that EGF and/or TGF-alpha produced by carcinoma cells function as autocrine growth factors for human esophageal carcinomas.
|
2298497 |
1990 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Human esophageal and gastric carcinomas express multi-autocrine growth factors and hormones including epidermal growth factor (EGF), transforming growth factor (TGF)-alpha and beta, platelet-derived growth factor (PDGF), insulin-like growth factor (IGF) and sex hormones.
|
2098274 |
1990 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Amplification of c-erbB-2 and EGF receptor genes has been observed in many metastatic sites of gastric carcinomas regardless of histological type.
|
2157713 |
1990 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that EGF and/or TGF-alpha produced by tumor cells act as autocrine growth factors for gastric carcinomas.
|
2108945 |
1990 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The biochemical determination of EGF-R demonstrated that EGF specific binding sites were detected in 36% of ovarian (n = 140) and 81% of cervical carcinomas (n = 42).
|
2697181 |
1990 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although the EGF receptor gene (c-erbB1) is overexpressed in nearly all carcinomas analyzed, there was no linear coexpression with the proTGF-alpha gene.
|
2354442 |
1990 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of cripto, a novel gene of the epidermal growth factor family, in human gastrointestinal carcinomas.
|
1938601 |
1991 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The phenotype of different malignant epithelial tumors including ovarian carcinomas is obviously associated with an activation of the EGF/TGFa signal pathway.
|
1746909 |
1992 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas.
|
1282800 |
1992 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We examined tyrosine kinase activity of epidermal growth factor (EGF) receptor in a total of 34 human gastric carcinomas as well as in non-neoplastic gastric mucosa from the same patients.
|
1594497 |
1992 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of amphiregulin, a novel gene of the epidermal growth factor family, in human gastric carcinomas.
|
8407551 |
1993 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of mRNAs for epidermal growth factor (EGF), transforming growth factor alpha(TGF alpha), EGFR, platelet-derived growth factor (PDGF) A and B chain, PDGF receptor (PDGFR), transforming growth factor beta (TGF beta), erbB-2 and estrogen receptor (ER) genes was first examined in 6 human esophageal carcinoma cell lines, 6 xenoplanted and 15 surgically resected esophageal carcinomas.
|
8491760 |
1993 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of pre-pro-TGF-alpha mRNA and pre-pro-EGF mRNA were significantly higher in CaP (n = 13) than BPH (n = 21) specimens (p < 0.05).
|
7508078 |
1993 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
EGF expression was unevenly distributed according to histological grade, indicating a lack of EGF immunoreactivity in poorly differentiated oesophageal carcinomas.
|
8166440 |
1994 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Epidermal growth factor expression in human colon and colon carcinomas: anti-sense epidermal growth factor receptor RNA down-regulates the proliferation of human colon cancer cells.
|
7558411 |
1995 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of cripto, a member of the epidermal growth factor (EGF) family, was examined by immunohistochemistry in benign lesions and carcinomas of the gall bladder.
|
8976875 |
1996 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significantly higher incidence (P < 0.05) of expression of the following was noted; TGF-alpha in the polypoid carcinomas with an adenoma component, and EGF and c-ERBB2 gene product in the carcinomas without an adenoma component.
|
8669884 |
1996 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The EGF-like family of proteins, such as epidermal growth factor (EGF), transforming growth factor alpha (TGFalpha), amphiregulin (AR), betacellulin (BTC), cripto-1 (CR-1), and heregulin (HRG), plays an important role in the pathogenesis of several human carcinomas as autocrine growth factors.
|
9648926 |
1998 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
All carcinomas and synchronous lesions but one showed high expression levels of the EGF receptor.
|
10534770 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upregulated epidermal growth factor (EGF) receptor (EGFR) expression and EGFR-induced signaling have been correlated with progression to invasion and metastasis in a wide variety of carcinomas, but the mechanism behind this is not well understood.
|
11359909 |
2001 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
From the observed clonal differences in the regulatory effects of EGF and 1,25-D3 on VDR and CYP27B1 gene expression we suggest that VDR-mediated growth inhibition by 1,25-D3 would be efficient only in highly differentiated carcinomas even when under mitogenic stimulation by EGF.
|
12027461 |
2002 |