|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transmembrane protein with epidermal growth factor-like and two follistatin-like domains 1 (TMEFF1) has an anticarcinogenic effect in brain tumors.
|
30697076 |
2019 |
|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The complex was incubated with brain cancer cell lines overexpressing the EGF receptor (EGFR) and transfected with the luciferase gene.
|
28532151 |
2018 |
|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Autocrine and paracrine factors, including glutamate and epidermal growth factor (EGF), are potent inducers of brain tumor cell invasion, a pathological hallmark of malignant gliomas.
|
30298963 |
2018 |
|
Brain Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
PKM2-regulated MLC2 phosphorylation, which is greatly enhanced by EGF stimulation or EGFRvIII, K-Ras G12V and B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumour development.
|
25412762 |
2014 |
|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we show the first example of this alternate mechanism in brain tumors by showing that EGF receptor (EGFR)-mutant glioblastomas (GBMs) evade EGFR TKIs by transcriptionally de-repressing platelet-derived growth factor receptor β (PDGFRβ).
|
23533263 |
2013 |
|
Brain Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The purpose of this study was to investigate the association between the single-nucleotide polymorphism of EGF+61G/A and extraaxial brain tumors in a population of the southeast of Brazil.
|
20303009 |
2010 |
|
Brain Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
One prominent molecular abnormality discovered in these astrocytic brain tumors is alteration of epidermal growth factor (EGF) receptor (EGFR) through gene amplification and/or mutation resulting in excessive signaling from this receptor.
|
17616668 |
2007 |
|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The authors have previously shown that DAB(389)EGF is selectively toxic to EGFR-overexpressing cells, including human brain tumour and lung carcinoma cell lines.
|
14519080 |
2003 |
|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Epidermal growth factor chimeric peptides have been used for neuroimaging of brain cancer.
|
11700018 |
2001 |
|
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Peptide radiopharmaceuticals such as radiolabeled EGF could be used to image early brain tumors, should these radiopharmaceuticals be made transportable through the BBB.
|
10626807 |
1999 |
|
Brain Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EGF receptor amplification and expression in human brain tumours.
|
1567659 |
1992 |
|
Brain Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results suggest that alterations of expression of the EGF receptor may play a role in human brain tumours.
|
1671751 |
1991 |
|
Brain Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that 4 of 10 primary brain tumours of glial origin which express levels of EGF receptors that are higher than normal also have amplified EGF receptor genes.
|
2981413 |
1985 |