|
Diphtheria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CRM197, a diphtheria toxin (DT) mutant, binds directly to the epidermal growth factor (EGF)-like domain and represses the mitogenic activity of HB-EGF.
|
21976708 |
2012 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRM197, a nontoxic mutant of diphtheria toxin, is a specific inhibitor of heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), which belongs to the EGF family that has been implicated in the increased progression, proliferation, and metastasis of oral cancer.
|
22718294 |
2012 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Addition of excess free EGF blocked transport of effector proteins into A431 cells via the fusion protein, but not via native PA. We also showed that fusing the diphtheria toxin receptor-binding domain to the C terminus of the mutated PA channeled effector-protein transport through the diphtheria toxin receptor.
|
22550037 |
2012 |
|
Diphtheria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The proliferative effects of uPA were inhibited by immunoneutralization of the EGF receptor and of heparin-binding EGF (HB-EGF) by the mutant diphtheria toxin CRM197 and an EGF receptor tyrosine kinase inhibitor.
|
18599586 |
2008 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diphtheria toxin-epidermal growth factor fusion protein and Pseudomonas exotoxin-interleukin 13 fusion protein exert synergistic toxicity against human glioblastoma multiforme cells.
|
14624623 |
2004 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
DAB(389)EGF is a fusion protein composed of the catalytic and translocation domains of diphtheria toxin fused via a His-Ala linker to human epidermal growth factor (EGF).
|
14519080 |
2003 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
DAB389EGF is a fusion protein composed of the catalytic and translocation domains of diphtheria toxin fused via a His-Ala linker to human epidermal growth factor (EGF).
|
12570681 |
2003 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells.
|
12702570 |
2003 |
|
Diphtheria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CRM9 is a mutant form of diphtheria toxin (DT) that binds less efficiently than wild-type DT to the DT receptor (proHB-EGF) of primates.
|
11571443 |
2001 |
|
Diphtheria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Estradiol signaling to Erk-1/-2 could be blocked by: 1) inhibiting EGF-receptor tyrosine kinase activity, 2) neutralizing HB-EGF with antibodies, or 3) down-modulating HB-EGF from the cell surface with the diphtheria toxin mutant, CRM-197.
|
11043579 |
2000 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is an activating ligand for the EGF receptor (HER1/ErbB1) and the high-affinity receptor for diphtheria toxin (DT) in its transmembrane form (proHB-EGF).
|
9518259 |
1998 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
HB-EGF protein is detectable on the surface of these cells by immunohistochemistry, and SUM-102PT cells are killed by diphtheria toxin, which acts by binding to HB-EGF.
|
9041204 |
1997 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although 3-fold greater levels of total cellular EGF receptor protein were detected in ME-180R cell lysates, and its cell surface localization was confirmed by immunodetection, these cells were paradoxically unable to bind greater quantities of 125I-EGF or to express greater cytotoxic sensitivity to an EGF-diphtheria toxin fusion protein.
|
8518234 |
1993 |