Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed the differential expression of potential target genes in a glioblastoma cell line in two nested RNAi experimental conditions and one negative control, contrasting expression with EGF stimulation against expression without EGF stimulation.
|
31438847 |
2019 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma.
|
31386654 |
2019 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, while under normoxic conditions, EGF stimulates the activation of both the PI3K and the MAPK pathways and the induction of VEGF, in glioblastoma cells, hypoxic conditions lead to the suppression of the PI3K/RhoA/C pathway and an exclusive switch to the MAPK pathway.
|
31698752 |
2019 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we found that expression of EphA3 is up-regulated in response to epidermal growth factor (EGF) stimulation and promotes formation of cell aggregates in suspension culture of glioblastoma cells.
|
30528229 |
2019 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TROY expression significantly increases the capacity of EGF to stimulate glioblastoma cell invasion, whereas depletion of TROY expression blocks EGF stimulation of glioblastoma cell invasion.
|
29117939 |
2018 |
Adult Glioblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism.
|
29029486 |
2017 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing.
|
27121290 |
2016 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.
|
25347738 |
2015 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The EGF receptor (EGFR) is amplified and mutated in glioblastoma, in which its common mutation (ΔEGFR, also called EGFRvIII) has a variety of activities that promote growth and inhibit death, thereby conferring a strong tumor-enhancing effect.
|
24436148 |
2014 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We further compared EGF +61 G/A polymorphism in patients with glioblastoma and Grade I-III glioma accordingly, the stronger association between the EGF +61 G/A polymorphism and the malignancy of glioma was found.
|
24740103 |
2014 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Temozolomide induces the production of epidermal growth factor to regulate MDR1 expression in glioblastoma cells.
|
25053824 |
2014 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells.
|
24012640 |
2014 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor (EGF)-enhanced vascular cell adhesion molecule-1 (VCAM-1) expression promotes macrophage and glioblastoma cell interaction and tumor cell invasion.
|
24045955 |
2013 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The EGF receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma.
|
23857604 |
2013 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have observed levels of phosphorylation of STAT5 at position Y699 in cells expressing ΔEGFR that are similar or higher than in cells that overexpress EGFR and are acutely stimulated with EGF, prompting us to investigate the role of STAT5 activation in glioblastoma.
|
22729867 |
2013 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The glioblastoma displayed EGF receptor amplification, and interestingly, it also displayed MYCN amplification; both tumors showed low level PTEN deletion.
|
22151431 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-level EGFR amplification was rapidly lost in 5 glioblastoma cultures supplemented with EGF, whereas it was preserved in cultures from the same tumors established without EGF.
|
22316604 |
2012 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also observed that RhoG is activated by both HGF and EGF, two factors that are thought to be clinically relevant drivers of glioblastoma invasive behavior, and that RhoG is overexpressed in human glioblastoma tumors versus non-neoplastic brain.
|
22966858 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of the Elk-1 led to an increased survival and a proliferative response with the EGF stimulation in the U138 glioblastoma cells.
|
22085529 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because oncogene MET and EGF receptor (EGFR) inhibitors are in clinical development against several types of cancer, including glioblastoma, it is important to identify predictive markers that indicate patient subgroups suitable for such therapies.
|
22203985 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
|
22891331 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
|
23284962 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A bispecific ligand-directed toxin (BLT), called EGFATFKDEL, consisting of human epidermal growth factor, a fragment of urokinase, and truncated pseudomonas exotoxin (PE38) was assembled in order to target human glioblastoma.
|
20830604 |
2011 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, ectopic expression of α-catenin or depletion of β-catenin suppresses EGF-promoted glioblastoma cell migration, invasion, and proliferation.
|
20872274 |
2011 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma.
|
21503828 |
2011 |