|
Malignant Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autocrine and paracrine factors, including glutamate and epidermal growth factor (EGF), are potent inducers of brain tumor cell invasion, a pathological hallmark of malignant gliomas.
|
30298963 |
2018 |
|
Malignant Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing.
|
27121290 |
2016 |
|
Malignant Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.
|
27165742 |
2016 |
|
Malignant Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor (EGF) receptors contribute to the development of malignant glioma.
|
24330607 |
2013 |
|
Malignant Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Malignant gliomas are associated with alteration in EGF/EGFR signaling.
|
22481252 |
2012 |
|
Malignant Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we examined the expression of EGF-like domain 7 (EGFL7), an endothelial cell-derived secreted factor, in malignant gliomas and explored its clinical significance.
|
20213100 |
2010 |
|
Malignant Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that a polymorphism in the 5'-untranslated region of the epidermal growth factor (EGF) gene, a natural ligand of the EGFR, may play a role in the genesis of these malignant gliomas.
|
14973082 |
2004 |
|
Malignant Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our purpose was to analyze retrospectively the prognostic input of platelet-derived growth factor receptor (PDGF-R), epidermal growth factor (EGF-R), and bcl-2 expression in 103 malignant gliomas from uniformly treated patients.
|
15048678 |
2004 |
|
Malignant Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Amplification and/or mutations of the epidermal growth factor (EGF) receptor have been frequently reported in human malignant gliomas, the most common primary tumor of the adult central nervous system.
|
11535237 |
2001 |
|
Malignant Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene amplification of erbB genes in human malignant gliomas was restricted to the EGF receptor (EGFR) gene, erbB-1.
|
7760096 |
1994 |
|
Malignant Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Polysomy and structural rearrangements of chromosome #7 could be related to the overexpression of epidermal growth factor gene, previously observed in some malignant gliomas.
|
2824025 |
1987 |
|
Malignant Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This may be exemplified by the human malignant glioma, in which the sis gene (encoding a growth factor homologous to PDGF) and the erb B gene (encoding a membrane protein homologous to the EGF receptor) have been implicated.
|
3001490 |
1985 |