|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
ELISA was performed to detect EGF concentration in co-culture system of M2-like TAMs and OC cell lines.
|
31062668 |
2019 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
HER3 is a member of the epidermal growth factor family and was predominantly described as a negative prognostic factor in various solid tumors as well as in ovarian cancer.
|
27913862 |
2017 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that high serum HB-EGF concentrations were significantly associated with poor prognosis in a combined cohort of patients with all stages of ovarian cancer, as well as in a subset of patients with advanced disease.
|
28668900 |
2017 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, HB-EGF is a molecular target for the resistance of ovarian cancer to paclitaxel and CRM197 as a HB-EGF-targeted agent might be a chemosensitizing agent for paclitaxel-resistant ovarian carcinoma.
|
26572150 |
2016 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological inhibition of c-Myc reduced HB-EGF induced glycolytic enzymes implicating a major role of c-Myc in loss of HSulf-1 mediated altered glycolytic pathway in OVCA.
|
26378042 |
2015 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data provide evidence that TNFR1 plays a critical role in ovarian cancer and show that the EGF induced signaling pathway is independent of the TNF-α triggering cascade signal.
|
26122654 |
2015 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor (EGF) activation of the EGF receptor (EGFR) is an important mediator of cell migration, and aberrant signaling via this system promotes a number of malignancies including ovarian cancer.
|
22315226 |
2012 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrate that EGF and LPA both stimulate production of LPA by OVCAR3 and SKOV3 human ovarian cancer cell lines.
|
19864325 |
2010 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to appraise the association between EGF gene A61G polymorphism with ovarian cancer susceptibility.
|
19144868 |
2009 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our objective was to correlate EGFR over-expression and growth inhibition, by EGF receptor inhibitors, in ovarian cancer.
|
18423824 |
2008 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
HB-EGF also plays a pivotal role in the progression of ovarian cancer.
|
18852147 |
2008 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of the epidermal growth factor (EGF) receptor (EGFR) is detected in human ovarian tumors and is associated with decreased recurrence-free and overall survival.
|
17475671 |
2007 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
The epidermal growth factor (EGF) and EGF receptor (EGFR) family are often overexpressed in various human cancers including ovarian cancer.
|
17045920 |
2006 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HB-EGF expression was significantly increased in advanced ovarian cancer compared with that in normal ovaries (P < 0.01).
|
16000575 |
2005 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation.
|
15921680 |
2005 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer.
|
14639658 |
2003 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
LHGDN |
Inhibition of the antiproliferative effect of TGFbeta by EGF in primary human ovarian cancer cells.
|
12879019 |
2003 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
All these data are consistent with E2 increasing production of TGFalpha in ER-positive ovarian cancer and this in turn acting through the EGF receptor to modulate growth in an autocrine manner.
|
9605408 |
1998 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Seventeen primary human ovarian cancer tissue samples were examined for the presence of EGF receptors by a 125I-EGF-binding study.
|
7954262 |
1994 |