|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Because EGFR expression by mesenchymal-like cells was diminished in the spheroid model and in human SCCs, we hypothesized that SCCs shift toward infiltrative invasion mediated by this subpopulation during anti-EGFR therapy.
|
23939378 |
2013 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Pathologically, the EGFR amplification rate of patients with squamous cell carcinoma was 56.52% (13/23), and with adenocarcinoma was 72.72% (16/22).
|
26400330 |
2015 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
EGFR-amplified tumors showed the highest fraction of squamous cell carcinoma (17%; n = 4 of 23).
|
22042947 |
2011 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Nuclear EGFR is associated with transcription, DNA synthesis, and DNA repair activity and serves as a prognostic marker in breast carcinoma and oropharyngeal squamous cell cancer.
|
17283074 |
2007 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The erbB oncogene, which encodes the epidermal growth factor receptor, is often highly expressed in epidermoid carcinomas.
|
2547647 |
1989 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
|
25723392 |
2015 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Particularly, EGFR was considered a strong predictor in laryngeal squamous cell cancer (HR > 2).
|
24038070 |
2013 |
|
Squamous cell carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proportion of patients with non-squamous carcinoma (in first-line setting), proportion of never-smokers (both in first- and second-line setting) and proportion of epidermal growth factor receptor (EGFR) mutant patients (both in first- and second-line setting) showed a moderate or strong correlation with median PFS.
|
28959160 |
2017 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that blockade of the epidermal growth factor receptor might be effective in inhibiting telomerase activity of squamous cell carcinomas, which would lead to the suppression of tumor growth.
|
14708611 |
2003 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
By using an established epidermoid carcinoma cell line (A-431), which overexpresses the epidermal growth factor receptor (EGFR) and transferrin receptor (TfnR), we show that aspirin (1) reduces cell surface expression of EGFR and (2) accumulates endocytosed-EGFR and -TfnR in the early/sorting endosome (ESE).
|
22159558 |
2012 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The murine IgG2a monoclonal antibody (mAb) EMD 55900 was produced against the human epidermoid carcinoma cell line A431, with binding occurring to the polypeptide chain of the external domain of human epidermal growth factor receptor (EGF-R).
|
8562040 |
1995 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas.
|
21498106 |
2011 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Detection of mutation-specific epidermal growth factor receptor (E746-A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma.
|
24818747 |
2014 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
EGFR expression was higher in SCC than in NSCC and correlated with +3q in the entire series.
|
17011066 |
2006 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.
|
2998610 |
1986 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The likely presence of E5 transcripts was neither associated to a higher activity of the EGFR-VEGFA pathway nor to the overall survival of patients with HPV16+ squamous cell carcinoma in stages ≥ IB2.This article is protected by copyright.All rights reserved.
|
31696949 |
2019 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma: a FISH study.
|
23521519 |
2013 |
|
Squamous cell carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Consistent with these findings, recent clinical studies have shown that epidermal growth factor receptor-mutant lung ADC can transdifferentiate to SCC in relapsed cancer patients.
|
28284717 |
2017 |
|
Squamous cell carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
EGFR TKIs could be an option for the treatment of SCC, and EGFR mutation detection can help to select a subgroup of patients who would have the best response to TKIs.
|
26725853 |
2016 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
|
20604875 |
2010 |
|
Squamous cell carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Paired genomic analysis from our sample provides early clinical evidence of the ADC to SCC lineage transition that might be provoked by an alteration in the PI3K/AKT/mTOR pathway during EGFR TKI treatment.
|
31319998 |
2019 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Enhanced mRNA expression was found only in one squamous cell carcinoma cell line, which is known to have high levels of epidermal growth factor receptor.
|
3581091 |
1987 |
|
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
T-cadherin-deficient SCC or human keratinocyte cells exhibited increased transendothelial migration in vitro which could be attenuated in the presence of EGFR inhibitor gefitinib.
|
23369463 |
2013 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma.
|
28694429 |
2017 |
|
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Correlation of epidermal growth factor receptor overexpression with increased epidermal growth factor receptor gene copy number in esophageal squamous cell carcinomas.
|
22490401 |
2012 |