Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Blocking EGFR signaling caused HGF-induced squamous tumors to regress, suggesting that EGFR inhibitors might be useful for treating squamous cell carcinomas.Listen to Podcast.
|
27330186 |
2016 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
EGFR is commonly overexpressed in penile cancer and in other squamous cell carcinomas.
|
27818285 |
2017 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
|
6328312 |
1984 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas.
|
15610907 |
2005 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We found EGFR expression is higher in the squamous cell carcinomas than in adenocarcinomas (p=0.043), and that nuclear p53 staining correlated with lower differentiated squamous tumors (p=0.034).
|
29731995 |
2018 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor alpha (TGF-alpha) and epidermal growth factor receptor (EGFR) have been shown to be present in most squamous cell carcinomas.
|
2752531 |
1989 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of ADAM10 in oral squamous cell carcinoma and its correlation with EGFR, neoangiogenesis and clinicopathologic factors.
|
31395417 |
2019 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Co-expression of EGFR and MET has a synergistic effect on the prognosis of patients with oral squamous cell carcinoma.
|
31762177 |
2020 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines.
|
12673202 |
2003 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Antitumor Efficacy of SLPI Promoter-Controlled Expression of Artificial microRNA Targeting EGFR in a Squamous Cell Carcinoma Cell Line.
|
28101799 |
2017 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.
|
28920960 |
2017 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
However, an adjacent gene (approximately 0.4 Mb), EGFR-co-amplified and overexpressed protein (ECOP), showed strong over-expression in the majority (90%) of SCCs regardless of gene amplification status.
|
19525979 |
2009 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus.
|
16161046 |
2006 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
EGFR gene copy number was positively correlated with EGFR protein expression among both AD samples (P=0.008) and SCC samples (P=0.042), with EGFR protein expression being significantly higher in SCC samples compared with AD (P=0.038).
|
22419022 |
2012 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
EGFR protein expression and gene amplification in squamous intraepithelial lesions and squamous cell carcinomas of the cervix.
|
24551297 |
2014 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
|
25873175 |
2015 |
Squamous cell carcinoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
|
21751261 |
2011 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that amplification of EGFR gene occurs in the relatively early stage of the development of oral SCC.
|
11564582 |
2001 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The anti-human epidermal growth factor receptor IgG conjugated to ZZ-BNC (α-hEGFR-ZZ-BNC) was endocytosed by the human epidermoid carcinoma A431 cells, with increases in cellular uptake by ∼1.5 fold, compared that of α-hEGFR IgG alone.
|
30641288 |
2019 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the epidermal growth factor receptor has been noted in many types of tumors and is associated with gene amplification in several including epidermoid carcinoma, lung carcinoma, breast carcinoma and glioblastoma.
|
2294252 |
1990 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cetuximab is a chimeric IgG1 monoclonal antibody that binds the EGFR with high specificity and have been developed as promising therapeutic anticancer treatments in several solid tumors, including colorectal and head and neck squamous cell carcinomas.
|
19212633 |
2009 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma.
|
21530363 |
2011 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion basal subtype was associated with response to EGFR directed therapy in head and neck squamous cell cancer patient-derived xenografts.
|
28560858 |
2017 |
Squamous cell carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
HR-HPV positivity is associated with decreased expression of the p53 and Rb genes, overexpression of p16, decreased expression of EGFR, and a different genetic expression pattern compared with patients with HR-HPV-negative SCCAs, leading to the conclusion that this is a distinct clinical entity.
|
19652580 |
2009 |
Squamous cell carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Together, our findings provide evidence that ΔNp63α expression is regulated by EGFR activation through STAT3 and that the EGFR-ΔNp63α axis is crucial for proliferation of TICs present in SCCs.
|
23018838 |
2013 |