|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
|
28927043 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
The expression of PD-L1 can be regulated by EGFR signaling activation in ESCC, which indicates an important role for EGFR-mediated immune escape and potential molecular pathways for EGFR-targeted therapy and immunotherapy.
|
28243112 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
TE-8 (mesenchymal-like ESCC cells)- or TE-11R (epithelial-like ESCC cells)-derived xenograft tumors in mice were treated with cetuximab, and the antitumor effects of EGFR inhibitors were evaluated.
|
28764725 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the expression of EGFR and IGF-1R in esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues in a tissue microarray was firstly detected by immunohistochemical staining.
|
28498434 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we proved that RhoE could negatively regulate the protein expression of EGFR and p-ERK, suggesting that RhoE might inhibit ESCC progression through the EGFR/ERK pathway.
|
27721256 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
For this phase 2, single-arm, multicenter trial undertaken at six hospitals in China, we included Chinese patients with previously treated, histologically confirmed advanced ESCC and EGFR overexpression (immunohistochemical staining sore of 3+) or amplification (positive fluorescence in situ hybridization result).
|
26980473 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Prognostic impact and potential interaction of EGFR and c-Met in the progression of esophageal squamous cell carcinoma.
|
26810066 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In summary, our results demonstrate that GBP1 promotes lymph node metastasis and has a positive correlation with EGFR expression in ESCC.
|
26760981 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of the current study was to elucidate a further finding on the clinicopathologic significance of immunohistochemical expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) in Chinese patients with ESCC.
|
26323923 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Lymph node metastasis, TNM stage, ADAM17 and EGFR protein expression may be used as independent prognostic indicators of esophageal squamous cell carcinoma (all P<0.05).
|
25351873 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
(2) The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree.
|
26099724 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC).
|
25795715 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusions, our study suggests that NCL is implicated in the initiation and transduction of EGFR and CXCR4 signaling and further up-regulates Ki67 expression to modulate the biological behaviors of ESCC.
|
25631630 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Overexpression and gene amplification of both ERBB2 and EGFR in an esophageal squamous cell carcinoma revealed by fluorescence in situ hybridization, multiplex ligation-dependent probe amplification and immunohistochemistry.
|
26314265 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients.
|
25081654 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
ESCC shows a relatively high incidence of EGFR (50% - 70%), and the humanized monoclonal antibody (mAb) cetuximab against EGFR has been undergoing clinical development.
|
25242085 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
EGFR:rs2227983 and 3 SNPs of PIK3CA also showed borderline significant correlation with OS of advanced ESCC patients (P = 0.058 for rs2227983; P = 0.069, 0.091 and 0.067 for rs6443624, rs7651265 and rs7621329 of PIK3CA respectively).
|
24945674 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
EGFR and c-Fos expression can predict the tumor stage. c-Fos and c-erb-B2 expression can be used to determine the depth of tumor invasion and can also act as a combined prognostic indicator in ESCC.
|
24052437 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Another esophageal squamous cell carcinoma cell line CE81T/VGH (CE81T) was found to be resistant to Photofrin-induced inhibition of EGFR as well as to Photofrin-mediated dark toxicity compared with CE48T.
|
22585382 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that KRAS and BRAF mutations play a limited role in the development of ESCC and that mutation analysis is not useful as a screening test for sensitivity to anti-EGFR therapy in ESCC.
|
23274581 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Identification of exon 19 and 21 mutations of EGFR gene in Chinese patients with esophageal squamous cell carcinoma.
|
24103528 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The authors retrospectively analyzed the hypermethylation status of 11 genes using methylation-specific polymerase chain reaction (PCR) and the expression of epidermal growth factor receptor (EGFR), O-6 methylguanine-DNA methyltransferase (MGMT), tumor protein 53 (p53), and transforming growth factor β (TGFβ) using immunohistochemistry in 329 formalin-fixed, paraffin-embedded ESCCs.
|
23310950 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population.
|
23874846 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that lapatinib has activity in EGFR- and/or HER2-expressing ESCC primary cells, and that lapatinib in combination with 5-FU may be a promising treatment strategy for patients with ESCC.
|
23708506 |
2013 |