|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the EGFR/Notch bispecific antibody PTG12 in combination with GDC-0941 exerted a stronger antitumor effect than the combined therapy of PI3K inhibitor with EGFR inhibitors or tarextumab in a broad spectrum of epithelial tumors.
|
30670492 |
2019 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Over expression of the epidermal growth factor receptor (EGFR) in many human epithelial tumors has been correlated with disease progression and poor prognosis.
|
29908541 |
2018 |
|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In clinical practice, various drugs target the well-characterized EGFR pathway in many epithelial tumors.
|
26245271 |
2016 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results support these predictions and suggest that targeted delivery of EGFR siRNA may be an effective strategy for the treatment of ovarian and other epithelial tumors associated with elevated levels of EGFR and especially those demonstrating resistance to platinum-based therapies.
|
27819259 |
2016 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptor (EGFR) is overexpressed in many epithelial tumors and its role in the development of non-small-cell lung cancer (NSCLC) is widely documented.
|
26295963 |
2015 |
|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The survival rate of epithelial tumor cells through the action of EGFR-TKI is related to E-cadherin expression.
|
26125777 |
2015 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A total of 19 canine gastric epithelial neoplasms (5 adenomas and 14 carcinomas) were retrospectively evaluated for EGFR/HER-2 immunohistochemical expression and KRAS mutational status.
|
24454858 |
2014 |
|
Epithelioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) is amplified or mutated in various human epithelial tumors.
|
24335351 |
2014 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.
|
23777544 |
2013 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial tumors and is considered to be an important therapeutic target.
|
21750651 |
2011 |
|
Epithelioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the possibility of the targeted therapy for human epidermal growth factor receptor (HER)-2 and epidermal growth factor receptor (EGFR) in ovarian cancers, we evaluated HER-2 and EGFR gene amplification by using chromogenic in-situ hybridization method in ovarian common epithelial tumors.
|
19652593 |
2010 |
|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor modulating the cell proliferation and biological progression of many human epithelial tumors.
|
20845818 |
2010 |
|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGFR is a major anticancer drug target in human epithelial tumors.
|
19759520 |
2009 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The steroid receptor coactivator amplified in breast cancer 1 (AIB1) as well as epidermal growth factor receptor (EGFR) family members are frequently overexpressed in epithelial tumors, and their expression is associated with poor prognosis.
|
17671194 |
2007 |
|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR/HER1) and its downstream signaling events are important for regulating cell growth and behavior in many epithelial tumors types.
|
17663798 |
2007 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The EGFR overexpression in many human epithelial tumors has been correlated with disease progression and bad prognosis.
|
16841332 |
2006 |
|
Epithelioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors.
|
16762968 |
2006 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) is overexpressed in many epithelial tumors and plays an important role in the tumorigenesis of these tumors.
|
15911107 |
2005 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB receptor family that is abnormally activated in many epithelial tumors.
|
15753456 |
2005 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family that is abnormally activated in many epithelial tumors.
|
12860957 |
2003 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EGFR is expressed in a high percentage of thymic epithelial tumors.
|
11935304 |
2002 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In some respects, the EGFR appears to be an attractive target for tumor-targeted antibody therapy: it is overexpressed in many types of epithelial tumor and inhibition of signaling often induces an anti-tumor effect.
|
11920591 |
2002 |
|
Epithelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The epidermal growth factor receptor family plays an important role in the pathogenesis of human epithelial tumors.
|
11236022 |
2000 |
|
Epithelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA amplification and/or mRNA overexpression of the epidermal growth factor receptor is associated with the malignant potential of several human epithelial tumors.
|
1729545 |
1992 |