Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal-inverted papilloma to squamous cell carcinoma.
|
30411788 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, the author concludes that p53 and EGFR are useful biomarkers for the diagnosis of leukoplakia and their risk of malignant transformation.
|
29516925 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Activating mutations in the kinase domain of epidermal growth factor receptor (EGFR) leads to the constitutively active kinase, improves the EGFR stability and promotes malignant transformation in lung adenocarcinoma.
|
29196224 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MiRNA-mRNA network and mRNA-mRNA network analysis showed that hsa-miR-320a, hsa-miR-331-3p, hsa-miR-26a-5p, hsa-miR-196a-5p, hsa-miR-221-3p, coiled-coil domain containing 180 (CCDC180), melanoma antigen gene family member D1 (MAGED1), membrane spanning 4-domains A7 (MS4A7), hephaestin like 1 (HEPHL1), BH3 (Bcl-2 homology 3)-like motif containing, cell death inducer (BLID), matrix metallopeptidase 13 (MMP13), guanylate binding protein 5 (GBP5), adipogenesis regulatory factor (ADIRF), formin homology 2 domain containing 1 (FHDC1), protein kinase CAMP-dependent type II regulatory subunit beta (PRKAR2B), nodium leak channel, non-selective (NALCN), myosin light chain kinase 3 (MYLK3), epidermal growth factor receptor (EGFR) and zinc finger protein 704 (ZNF704) were key miRNAs and genes in the malignant transformation induced by MC-LR in L02 cells.
|
29518473 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, CMP and its ingredient cordycepin can inhibit tumor growth and malignant transformation in a mouse model for oral cancer via inhibition of EGFR- and IL-17RA-signaling and enhancement of anti-tumor immunity.
|
29212184 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Abnormal EGFR GCN is a potential biomarker for identifying OPMD that are at risk of malignant transformation.
|
27197272 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The SPINK1 protein seems to play a role in tumor proliferation and malignant transformation through the EGFR pathway.
|
26037168 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
One of the keys for targeting ERBB2 will be to consider the entire ERBB family and downstream associated pathways responsible for the malignant transformation.
|
26452383 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.
|
26065894 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The three oncogenes, ErbB receptors, Ras proteins and nucleolin may contribute to malignant transformation.
|
25261371 |
2014 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Oral pre-malignant lesions with overexpression of EGFR or egfr gene copy number gain are at higher risk for malignant transformation.
|
24412287 |
2014 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Malignant transformation of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation may be related to the epidermal growth factor receptor pathway in this case, with atypical epithelial cell proliferation as a precursor.
|
24482415 |
2014 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Expression of epidermal growth factor receptor (EGFR) has been suggested to be associated with the malignant transformation of pancreatic cancer.
|
21573507 |
2011 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Disregulation of HER1/EGFR is related to malignant transformation and tumor growth in various human cancers, including malignant glioma.
|
20657384 |
2010 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Multiple mechanisms, including activation of EGFR or inflammatory cell signaling pathway, have been implicated in malignant transformation by HPV 16 E5.
|
20643111 |
2010 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We studied the activation status of the Wnt and Notch pathways and the differential expression of hepatocyte nuclear factor 4alpha, EGFR, and IGF2 genes, relevant to liver development and malignant transformation in histologic variants of hepatoblastoma.
|
19200579 |
2009 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A role for the EGF system, in particular HER1 and 2, in growth of the endometrium has been suggested but HER1 and 2 have not been studied in all locations of endometriosis and in ovarian endometrioid adenocarcinoma (OEC) which is a rare form of malignant transformation of endometriosis.
|
19294416 |
2009 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Recent studies have suggested that activation of the EGFR pathway leads to malignant transformation only if the p53 protein is inactivated.
|
19367287 |
2009 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A role for EGFR in the malignant transformation from IP to SCC of the nasal cavity is suggested.
|
18231801 |
2008 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Genetic alterations of the proto-oncogene human epidermal growth factor receptor (HER-2/neu) have been shown to induce malignant transformation and metastasis.
|
18837888 |
2008 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The over-expression of the epidermal growth factor receptor (EGFR) is associated with the majority of ovarian cancer and has been implicated in the process of malignant transformation by promoting cell proliferation, survival, and motility.
|
17601710 |
2007 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival.
|
17390112 |
2007 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The data support the hypothesis that increased epidermal growth factor receptor (EGFR) and transforming growth factor (TGF)-alpha expression is associated with early events in malignant transformation of pleomorphic adenoma (PA).
|
17851915 |
2007 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Some molecules, such as protein kinase C and the epidermal growth factor receptor-tyrosine kinase, play central roles in cellular activity and are involved in many of the different signaling pathways underlying malignant transformation.
|
14641991 |
2003 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Malignant transformation and EGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma.
|
10699924 |
2000 |