EGR1, early growth response 1, 1958

N. diseases: 378; N. variants: 3
Disease: Pneumonitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.310 Therapeutic disease CTD_human Taken together, our data reveal novel Egr-1 signaling that mediates the NF-κB and AP-1 pathways to orchestrate PM-induced pulmonary inflammation and mucus hyperproduction, suggesting that Egr-1 inhibition could be an effective therapeutic approach for airway disorders or disease exacerbations induced by airborne particulate pollution. 29787794 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.310 Biomarker disease BEFREE The objective of this study was to explore the possible role of early growth response gene 1 (Egr-1) in PM-induced toxic effects in pulmonary inflammation and mucus hyperproduction in vitro and in vivo. 29787794 2018