|
Cocaine-Related Disorders
|
0.500 |
Therapeutic
|
group |
RGD |
Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor.
|
25309368 |
2014 |
|
Cocaine-Related Disorders
|
0.500 |
Therapeutic
|
group |
RGD |
Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats.
|
21309948 |
2011 |
|
Cocaine-Related Disorders
|
0.500 |
Therapeutic
|
group |
CTD_human |
Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats.
|
18311559 |
2008 |
|
Cocaine-Related Disorders
|
0.500 |
Biomarker
|
group |
CTD_human |
Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats.
|
18311559 |
2008 |
|
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
Crosstalk between thrombosis and inflammation in lung reperfusion injury.
|
16488723 |
2006 |
|
Cocaine-Related Disorders
|
0.500 |
Therapeutic
|
group |
CTD_human |
Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation.
|
16738229 |
2006 |
|
Cocaine-Related Disorders
|
0.500 |
Biomarker
|
group |
CTD_human |
Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation.
|
16738229 |
2006 |
|
Cocaine-Related Disorders
|
0.500 |
Therapeutic
|
group |
CTD_human |
Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior.
|
16157275 |
2005 |
|
Cocaine-Related Disorders
|
0.500 |
Biomarker
|
group |
CTD_human |
Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior.
|
16157275 |
2005 |
|
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets.
|
12468449 |
2002 |
|
Malignant neoplasm of prostate
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate using a PC model (DU145/RasB1) of bone and brain metastasis that EGR1 expression regulates angiogenic and osteoclastogenic properties of metastases.
|
31312026 |
2019 |
|
Malignant neoplasm of prostate
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of EGR1 expression in PCa cells revealed it was required for the OCy-derived GDF15-mediated induction of in vitro PCa cell proliferation, migration and invasion.
|
30755731 |
2019 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Secondly, miR-181a-5p was down-regulated in clinical HCC specimens and its expression was inversely correlated with Egr1 expression.
|
30503931 |
2019 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present study illustrates that for HepG2 human hepatocellular carcinoma cells the signaling pathways triggered by ER stress extend beyond the three principal pathways to include mitogen-activated protein kinase (MAPK) signaling, leading to activation of transcription from the early growth response 1 (EGR1) gene.
|
30290239 |
2019 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study demonstrated that EGR1-induced upregulation of lncRNA FOXD2-AS1 promotes the progression of hepatocellular carcinoma via epigenetically silencing DKK1 and activating Wnt/β-catenin signaling pathway.
|
30929558 |
2019 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Quantitative real-time polymerase chain reaction (qPCR) and Western blotting were performed to detect CD24 and EGR1 expression in HCC cells and tissue.
|
30881025 |
2019 |
|
Malignant neoplasm of prostate
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpression of Egr-1 attenuated the effects of GCN5 silence on cell proliferation, migration, invasion, and EMT in PCa.
|
30333255 |
2018 |
|
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Effects of the combination of As<sub>2</sub>O<sub>3</sub> and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1.
|
29910624 |
2018 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we speculated that miR-181a-5p, which was upregulated in HCC tissues, could regulate FOS and EGR1 to promote the invasion and progression of HCC by p53 signaling pathway.
|
30228980 |
2018 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3.
|
29378599 |
2018 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Network analysis revealed that several miRNAs such as miR-381-3p, miR-142a-3p, miR-214-3p and TFs such as Egr1, Atf3 and Klf4 were the core regulators in HCC.
|
29254483 |
2017 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that Egr-1 contributes to HCC radioresistance through directly upregulating target gene Atg4B, which may serve as a protective mechanism by preferential activation of the autophagy.
|
28134935 |
2017 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
BEFREE |
Incidental support for the possibility of EGR1 being a regulator of hTERT expression in PCa was provided by i) immunolocalization of hTERT and EGR1 proteins in the same cell type (secretory epithelium) of PCa and BPH tissues; ii) significantly (p< 0.001) higher levels of both these proteins in CRPC (PC3 and DU145), compared with ADPC (LNCaP) cells.
|
27003515 |
2016 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Accordingly, it is suggested that a mechanism of hypoxia/Egr-1/autophagy axis might be involved in drug resistance in HCC.
|
26708617 |
2016 |