|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Importantly, when these cells were used to produce estrogen-dependent xenograft tumors in SCID mice, we also observed lower ERα protein levels and a reduced tumor mass, implying a tumor-suppressive-like function of the AhR in MCF7 xenograft tumors.
|
28416634 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Over-expression of AHR in GH3 cells revealed a tumour suppressor potential independent of exogenous ligand activation by benzo α-pyrene (BαP).
|
28649092 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment.
|
28318896 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Activity-to-exposure ratio (AER) values were calculated to compare relative risks of activating the aryl hydrocarbon receptor (AhR), nuclear factor erythroid 2-related factor 2 (Nrf2), and tumor suppressor gene (p53) when children or adults were exposed to fine or coarse PM in different seasons.
|
29192765 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In an in vivo xenograft mouse model transplanted with MCF-7 CV cells, the protein expression levels of AhR and CYP1A1 of tumor masses were also increased by E2 or TCDD.
|
28618207 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Blocking the IDO/AhR metabolic circuitry not only abrogates IFN-γ-induced dormancy but also results in enhanced repression of tumour growth by IFN-γ-induced apoptosis of TRCs both in vitro and in vivo.
|
28488695 |
2017 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Patients whose tumors harbored mutant BRAFV600E (AHR, 2.45; 95% CI, 1.85-3.25; P < .001) or mutant KRAS (AHR, 1.21; 95% CI, 1.00-1.47; P = .052) had worse SAR compared with those whose tumors had wild-type copies of both genes, although only results for BRAFV600E achieved statistical significance.
|
28006055 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma.
|
27283490 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A novel mechanism by which the AHR may play a direct role in pituitary cell proliferation and tumor formation is postulated.
|
28634910 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
On the other hand, in the tumor tissue from human colon cancer and that developed in Apc(Min/+)mice, AhR expression was elevated.
|
26973338 |
2016 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The net biologic effect of AHR activation by endogenous ligands, which can be mimicked by environmental ligands, is an increase in tumor cell migration, a measure of tumor aggressiveness.
|
27573671 |
2016 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The data demonstrate that: (i) primary OSCC tissue expresses elevated levels of nuclear AhR as compared with normal tissue, (ii) AhR mRNA expression is upregulated in 320 primary OSCCs, (iii) AhR hyperactivation with several ligands, including environmental and bacterial ligands, significantly increases AhR activity, ALDH1 activity, and accelerates cell migration, (iv) AhR inhibition blocks the rapid migration of OSCC cells and reduces cell chemoresistance, (v) AhR knockdown inhibits tumorsphere formation in low adherence conditions, and (vi) AhR knockdown inhibits tumor growth and increases overall survival in vivo These data demonstrate that the AhR plays an important role in development and progression of OSCC, and specifically cancer stem-like cells.
|
27130942 |
2016 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activated aryl hydrocarbon receptor (AhR) has an important influence on the development of tumors through its interactions with the cell cycle.
|
26514676 |
2016 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell.
|
26242870 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This review will summarize recent findings on the interesting and complicated underlying mechanisms that miRNAs interact with HIFs or AHR in tumors, hopefully to benefit the discovery of novel drug-interfering targets for cancer therapy.
|
25997457 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we sought to identify putative novel targets of the AHR associated with enhanced tumor invasiveness.
|
23625689 |
2014 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Evidence from transfection studies implies that AIP acts as a tumor suppressor; although whether this is mediated through an interaction with the aryl hydrocarbon receptor, phosphodiesterases, or with cell cycle regulators such as survivin or RET remains controversial.
|
24366639 |
2014 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
However, the AhR can also inhibit cellular proliferation in a ligand-dependent manner and act as a tumor suppressor in mice, and thus may be a potential anticancer target.
|
24481452 |
2014 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, AIP is involved in the aggressiveness of sporadic GH-PA, regardless of Gsp status, and AIP up-regulation in SSA-treated tumours is associated with a better preoperative response, with no clear role for AHR.
|
23940012 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of IGF2 was higher in tumors than in healthy lung tissue in never-smokers (p=0.003), and expression of AHR (p<0.0001), CSF1R (p<0.0001) and RRAD (p<0.0001) was lower in tumors than in healthy lung tissue in smokers.
|
24451080 |
2013 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line.
|
23733406 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings led to the hypothesis that the basal AhR activity in HNSCCs plays a role in the aggressive phenotype of these tumors and that antagonist treatment could mitigate this phenotype.
|
22912337 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Microarray analysis revealed aryl hydrocarbon receptor (AhR) signalling as one of the top networks that is differentially regulated in MCF7(TAM-R) and MCF7 xenograft tumours treated with AMD3100.
|
22644306 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.
|
22037238 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, this study evaluated whether the AhR serves a pro-proliferative role in an immortalized MB tumor cell line (DAOY).
|
22311706 |
2012 |