Congenital nystagmus
|
0.500 |
Biomarker
|
disease |
CTD_human |
Oculomotor deficits in aryl hydrocarbon receptor null mouse.
|
23301081 |
2013 |
Obesity
|
0.450 |
Biomarker
|
disease |
CTD_human |
The data demonstrate an important AHR-FGF21 regulatory axis that influences adipose biology and may represent a "druggable" therapeutic target for obesity and its related metabolic disorders.
|
30813227 |
2019 |
Obesity
|
0.450 |
Biomarker
|
disease |
CTD_human |
Studies are presented showing that the AHR antagonists α-naphthoflavone and CH-223191 significantly reduce obesity and adiposity and ameliorates liver steatosis in male C57Bl/6J mice fed a Western diet.
|
27020609 |
2016 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.
|
30346592 |
2019 |
Colitis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
|
27783946 |
2016 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Dioxins are known to cause several human cancers through activation of the aryl hydrocarbon receptor (AhR).
|
22037238 |
2012 |
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.
|
22037238 |
2012 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
CTD_human |
In summary this study showed the dual prognostic role of Gd especially in premenopausal breast cancer which could be induced by AhR overexpression.
|
22296396 |
2011 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
CTD_human |
Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.
|
21515334 |
2011 |
Neoplasm Metastasis
|
0.400 |
Therapeutic
|
phenotype |
CTD_human |
To test the effect of AhR activation on metastasis, 4T1.2 mammary tumor cells were injected into the mammary gland fat pad of syngeneic Balb/c mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
|
21948867 |
2011 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
In summary this study showed the dual prognostic role of Gd especially in premenopausal breast cancer which could be induced by AhR overexpression.
|
22296396 |
2011 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.
|
21515334 |
2011 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
To test this hypothesis and determine whether the mouse Ahr gene acts as a tumor suppressor gene in vivo, we have examined the role of Ahr ablation in liver tumorigenesis induced by the genotoxic chemical diethylnitrosamine (DEN), a hepatic carcinogen that is not an AHR ligand.In mice given a single i.p. injection of DEN, AHR antagonized liver tumor formation and growth by regulating cell proliferation, inflammatory cytokine expression, and DNA damage, parameters which were significantly elevated in the livers of control and, more so, of DEN-exposed Ahr-/- mice.
|
19996281 |
2010 |
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
CTD_human |
This phenomenon could be ligand independent, as the AhR ligand 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) did not alter prostate cancer cell growth.
|
20140206 |
2010 |
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis.
|
18617548 |
2008 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
CTD_human |
Overexpression of aryl hydrocarbon receptor in human lung carcinomas.
|
12597446 |
2003 |
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
CTD_human |
Association between glycodelin and aryl hydrocarbon receptor in Iranian breast cancer patients: impact of environmental endocrine disrupting chemicals.
|
22296396 |
2011 |
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
CTD_human |
Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.
|
21515334 |
2011 |
Hypertensive disease
|
0.360 |
Biomarker
|
group |
CTD_human |
We also report that Ahr- and Vav3-deficient mice display hypertension, tachypnea, and sympathoexcitation.
|
21115475 |
2011 |
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
CTD_human |
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.
|
12107286 |
2002 |
Metabolic Diseases
|
0.350 |
Biomarker
|
group |
CTD_human |
Further, dietary TCDF inhibited the farnesoid X receptor (FXR) signaling pathway, triggered significant inflammation and host metabolic disorders as a result of activation of bacterial fermentation, and altered hepatic lipogenesis, gluconeogenesis, and glycogenolysis in an AHR-dependent manner.
|
25768209 |
2015 |
Atherosclerosis
|
0.350 |
Biomarker
|
disease |
CTD_human |
We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta.
|
22228805 |
2012 |
Malignant neoplasm of liver
|
0.340 |
Biomarker
|
disease |
CTD_human |
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon receptor (Ahr) in rodents.
|
30346592 |
2019 |
Male infertility
|
0.340 |
Biomarker
|
phenotype |
CTD_human |
To address this possibility, we conducted a study including 580 idiopathic infertile subjects and 580 fertile controls to assess associations between the male infertility risk and six tagging single nucleotide polymorphisms of AHR gene.
|
21613234 |
2011 |
Malignant neoplasm of liver
|
0.340 |
Biomarker
|
disease |
CTD_human |
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.
|
19996281 |
2010 |