|
Metabolic Syndrome X
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease.
|
30670052 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fetuin-A is a glycoprotein produced in the liver and related to metabolic syndrome; fetuin-A secretion is divergently regulated in different pathological conditions.
|
30123261 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines related to insulin resistance and MetS in children are tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, interferon gamma, pigment epithelium-derived factor, chemerin, vaspin, and fetuin A. Anti-inflammatory cytokines associated with insulin resistance and MetS in children are leptin, adiponectin, omentin, fibroblast growth factor (FGF)-21, osteocalcin, and irisin.
|
30338401 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
For fetuin-A (ng/ml), MetS (5784) and MetS pre/T2DM (2154) were lower <i>versus</i> control (6756.3) (<i>p =</i> 0.040 and <i>p</i> = 0.007, respectively).
|
30515292 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma fetuin-A is associated with type 2 diabetes, and AHSG, the gene encoding fetuin-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome.
|
28379451 |
2017 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Circulating fetuin-A did not change during the 6 months either in the whole population or in the subgroups of patients who were positive for each individual component of MetS at baseline and negative for this component at 6 months of follow-up, except for hypertriglyceridaemia [reduction of serum fetuin-A levels (p=0.046)].
|
29278516 |
2017 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in alpha-2-Heremans-Schmid glycoprotein (AHSG), the gene which codes FetA, may influence metabolic syndrome progression in higher-risk ethnic groups.
|
28858873 |
2017 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both LBP and Fetuin-A correlated significantly with HOMA-IR and increased significantly with increasing features of MetS.
|
25978344 |
2015 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
All three biomarkers exhibited sexual dimorphisms (levels higher in women for fetuin-A and FABP4 but greater in men for RBP4) and were associated positively with insulin resistance assessed using the homeostasis model, with high-sensitivity C-reactive protein, and with prevalent MetSyn (P<0.01 for all).
|
22855337 |
2012 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent experimental and clinical studies also suggest an intriguing link between fetuin-A, insulin resistance, and the metabolic syndrome.
|
19004191 |
2008 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, there were significant differences in the prevalence of metabolic syndrome criteria between the AHSG Thr256Ser (C-G) genotype groups, with a more atherogenic lipid profile in AHSG high producers (Thr/Thr homozygotes).
|
18337634 |
2008 |
|
Metabolic Syndrome X
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Our objective was to study the longitudinal relationships between fetuin-A, NAFLD, and MetS in obese children.
|
18728159 |
2008 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
LHGDN |
Higher human fetuin-A concentrations are strongly associated with MetS and an atherogenic lipid profile.
|
16567568 |
2006 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The AHSG gene, consisting of seven exons and spanning 8.2 kb of genomic DNA, is located at chromosome 3q27, a susceptibility locus for type 2 diabetes and the metabolic syndrome.
|
16046317 |
2005 |